The effect of gastrointestinal bleeding on outcomes of patients with acute pancreatitis: a national population-based study

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Hsiu-Nien ShenChung-Yi Li

Abstract

To investigate the adverse effect of gastrointestinal bleeding (GIB) in patients with acute pancreatitis (AP), accounting for the status of organ failure (OF). We analyzed 107,349 patients with first-attack AP from the Taiwan National Health Insurance Research Database between 2000 and 2009. Patients were categorized into four groups according to the status of GIB and OF, the effect of which was assessed using multivariable analyses with generalized estimating equations models. Primary outcomes were 14-day and hospital mortality. Secondary outcomes were septic complication and prolonged hospital stay (>18 days). The covariate-adjusted odds ratio for 14-day mortality, hospital mortality, septic complication, and prolonged stay all significantly increased at 4.63 (95% confidence interval [CI] 3.80-5.63), 4.22 (95% CI 3.66-4.87), 3.52 (95% CI 3.03-4.08), and 1.27 (95% CI 1.20-1.35), respectively for the patients with OF only (n = 88,561). The corresponding figures for the patients with GIB only (n = 5184) were lower but still significant at 1.44 (95% CI 1.09-1.91), 1.42 (95% CI 1.15-1.75), 1.54 (95% CI 1.19-2.00), and 1.38 (95% CI 1.28-1.48). The co-existence of GIB in patients with OF (n = 1663) showed little additional risk of a...Continue Reading

Citations

Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
May 16, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·L CompañyM Pérez-Mateo
May 18, 2004·ANZ Journal of Surgery·Richard FlintMartin Bonham
Dec 16, 2004·Critical Care Medicine·Avery B NathensCarl S Waldmann
Jul 27, 2006·Pancreas·Timothy B GardnerDouglas J Robertson
Apr 30, 2008·World Journal of Gastroenterology : WJG·Ming-Jun XinJia-Bang Sun
May 24, 2008·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Timothy B GardnerBret T Petersen
Jul 11, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Damian J MoleRowan W Parks
Aug 7, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·G GravanteA R Dennison
Sep 22, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Anand SinglaShimul A Shah

Related Concepts

Peptic Ulcer
Acute Pancreatitis
Mucositis
Pseudoaneurysm
Pancreatitis
False Aneurysm of Artery
Acute Disease
Adverse Effects
Odds Ratio
Haemoconcentration

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