The effect of gender on the neuroanatomy of children with autism spectrum disorders: a support vector machine case-control study

Molecular Autism
Alessandra ReticoSara Calderoni

Abstract

Genetic, hormonal, and environmental factors contribute since infancy to sexual dimorphism in regional brain structures of subjects with typical development. However, the neuroanatomical differences between male and female children with autism spectrum disorders (ASD) are an intriguing and still poorly investigated issue. This study aims to evaluate whether the brain of young children with ASD exhibits sex-related structural differences and if a correlation exists between clinical ASD features and neuroanatomical underpinnings. A total of 152 structural MRI scans were analysed. Specifically, 76 young children with ASD (38 males and 38 females; 2-7 years of age; mean = 53 months, standard deviation = 17 months) were evaluated employing a support vector machine (SVM)-based analysis of the grey matter (GM). Group comparisons consisted of 76 age-, gender- and non-verbal-intelligence quotient-matched children with typical development or idiopathic developmental delay without autism. For both genders combined, SVM showed a significantly increased GM volume in young children with ASD with respect to control subjects, predominantly in the bilateral superior frontal gyrus (Brodmann area -BA- 10), bilateral precuneus (BA 31), bilateral s...Continue Reading

References

Oct 1, 1985·Cognition·S Baron-CohenU Frith
Apr 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·L Y Tsai, J M Beisler
Oct 1, 1981·Psychiatry Research·L Wing
Dec 1, 1993·Journal of Autism and Developmental Disorders·F R VolkmarS S Sparrow
Jul 2, 1998·Brain : a Journal of Neurology·M M Mesulam
Jul 2, 1999·Brain : a Journal of Neurology·M St GeorgeM I Sereno
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·A IshaiJ V Haxby
Sep 24, 1999·Nature Neuroscience·J N GieddJ L Rapoport
May 16, 2000·Brain Research. Cognitive Brain Research·T W BuchananL Jäncke
May 29, 2000·Trends in Cognitive Sciences·G BushM I Posner
Jun 10, 2000·Journal of Neurophysiology·K D DavisJ O Dostrovsky
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Nov 30, 2000·European Child & Adolescent Psychiatry·A NydénC Gillberg
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
May 28, 2002·Development and Psychopathology·Julie A OsterlingJeffrey A Munson
Jun 1, 2002·Trends in Cognitive Sciences·Simon Baron-Cohen
Aug 31, 2002·NeuroImage·Ruth A CarperEric Courchesne
Feb 14, 2003·Trends in Cognitive Sciences·Helen L. Gallagher, Christopher D. Frith
Sep 24, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth R SowellArthur W Toga
Oct 22, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew K BelmonteSara J Webb
Nov 8, 2005·Science·Simon Baron-CohenMatthew K Belmonte
Dec 7, 2005·Archives of General Psychiatry·Heather Cody HazlettJoseph Piven
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Jul 5, 2006·Acta Neuropathologica·Manuel F CasanovaChristoph Schmitz
Jan 12, 2007·Journal of Autism and Developmental Disorders·Alice S CarterHelen Tager-Flusberg
Apr 11, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Cinnamon S Bloss, Eric Courchesne
May 11, 2007·Developmental Medicine and Child Neurology·Martin HoltmannFritz Poustka
Sep 1, 2007·NeuroImage·John Ashburner
Sep 4, 2007·European Psychiatry : the Journal of the Association of European Psychiatrists·Andrew C StanfieldStephen M Lawrie
Oct 30, 2007·Neuron·Eric CourchesneJohn Morgan
Jan 19, 2008·Brain : a Journal of Neurology·Stefan KlöppelRichard S J Frackowiak
Feb 9, 2008·Trends in Neurosciences·David G AmaralChristine Wu Nordahl
Jul 3, 2008·Journal of Autism and Developmental Disorders·Ryan BanachWilliam Mahoney
Jul 17, 2008·Journal of Autism and Developmental Disorders·Tomonori KoyamaHiroshi Kurita
Oct 7, 2008·NeuroImage·Catherine J Stoodley, Jeremy D Schmahmann
Nov 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca C KnickmeyerJohn H Gilmore
Dec 17, 2008·Journal of Autism and Developmental Disorders·Katherine GothamCatherine Lord
Feb 27, 2009·Psychiatry Research·Sara Jane WebbStephen R Dager
Oct 1, 2007·Current Directions in Psychological Science·Peter Mundy, Lisa Newell
Aug 18, 2009·Vision Research·David R SimmonsFrank E Pollick

❮ Previous
Next ❯

Citations

Oct 5, 2016·Brain, Behavior, and Immunity·Lourdes Fernández de CossíoGiamal N Luheshi
Nov 23, 2016·Autism Research : Official Journal of the International Society for Autism Research·Xiang XiaoXiaoyan Ke
Mar 6, 2018·Current Psychiatry Reports·Sarah L FerriEdward S Brodkin
Sep 19, 2017·The European Journal of Neuroscience·Edoardo PappaianniAlessandro Grecucci
Jan 24, 2020·Journal of Anatomy·Andrea PironeVincenzo Miragliotta
Nov 22, 2016·Journal of Neuroscience Research·Meng-Chuan LaiSimon Baron-Cohen
Nov 22, 2016·Journal of Neuroscience Research·Neda Jahanshad, Paul M Thompson
Jun 5, 2017·Scientific Reports·Marina A PavlovaElisa Fazzi
Aug 28, 2020·PloS One·Leora AllenLidia V Gabis
Dec 19, 2018·Brain Structure & Function·Sabrina van HeukelumJ C Glennon
Jul 6, 2019·Frontiers in Psychiatry·Sanna StrothLaura Müller-Pinzler
May 24, 2020·The Cerebellum·Joel CrucittiMark A Stokes
Dec 20, 2018·Cerebral Cortex·Élodie CauvetSven Bölte
Oct 1, 2016·Journal of Neuroscience Research·Marina A Pavlova
Nov 2, 2019·Nature Communications·Merel C PostemaClyde Francks
Feb 16, 2021·Frontiers in Integrative Neuroscience·Margherita ProsperiStefano Vicari
Feb 16, 2017·Brain, Behavior, and Immunity·Sarah J Spencer, Urs Meyer
Mar 14, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Christopher HammillMeng-Chuan Lai
Mar 27, 2021·Autism Research : Official Journal of the International Society for Autism Research·Zhizhou Deng, Suiping Wang
Mar 28, 2021·Scientific Reports·Sharmistha SahaKanchan Mukhopadhyay
Apr 9, 2021·Frontiers in Neuroscience·Zhihong LanTianyue Wang
May 6, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Michele AvanzoGiovanni Mettivier
Jul 2, 2021·Frontiers in Genetics·Yenching LinShinn-Ying Ho

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

LPO
New Segment ” SPM
SVM
- Light
ABIDE
Statistical Parametric Mapping ( SPM ) SPM8
Statistic Parametric Mapping ( SPM )
DARTEL

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.