The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3 )2 (phenanthridine)Cl]NO3

Chemical Communications : Chem Comm
Wen ZhouS J Lippard

Abstract

A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.

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Citations

Apr 29, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Issiah B LozadaDavid E Herbert
Jan 10, 2019·European Journal of Medicinal Chemistry·Faiz-Ur RahmanDan-Wei Zhang
Feb 11, 2021·Pharmaceuticals·Suxing JinXiaoyong Wang
Jan 3, 2019·Journal of the American Chemical Society·Ali A AlmaqwashiMark C Williams
Apr 4, 2019·Journal of the American Chemical Society·Đenana MiodragovićThomas V O'Halloran
Sep 7, 2018·Journal of the American Chemical Society·Daniele VeclaniJosé P Cerón-Carrasco

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Methods Mentioned

BETA
X-ray
fluorescence microscopy
atomic absorption spectroscopy
electrophoresis

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