The effect of gestational age and cervical length measurements in the prediction of spontaneous preterm birth in twin pregnancies: an individual patient level meta-analysis

BJOG : an International Journal of Obstetrics and Gynaecology
L M KindingerT G Teoh

Abstract

To assess the effect of gestational age (GA) and cervical length (CL) measurements at transvaginal ultrasound (TVUS) in the prediction of preterm birth in twin pregnancy. Individual patient data (IPD) meta-analysis. International multicentre study. Asymptomatic twin pregnancy. MEDLINE and EMBASE searches were performed and IPD obtained from authors of relevant studies. Multinomial logistic regression analysis determined probabilities for birth at ≤28(+0) , 28(+1) to 32(+0) , 32(+1) to 36(+0) , and ≥36(+1) weeks as a function of GA at screening and CL measurements. Predicted probabilities for preterm birth at ≤28(+0) , 28(+1) to 32(+0) , and 32(+1) to 36(+0) . A total of 6188 CL measurements were performed on 4409 twin pregnancies in 12 studies. Both GA at screening and CL had a significant and non-linear effect on GA at birth. The best prediction of birth at ≤28(+0) weeks was provided by screening at ≤18(+0) weeks (P < 0.001), whereas the best prediction of birth between 28(+1) and 36(+0) weeks was provided by screening at ≥24(+0) weeks (P < 0.001). Negative prediction value of 100% for birth at ≤28(+0) weeks is achieved at CL 65 mm and 43 mm at ultrasound GA at ≤18(+0) weeks and at 22(+1) to 24(+0) weeks, respectively. In twin...Continue Reading

Associated Clinical Trials

Feb 23, 2017·Mario Henrique Burlacchini de Carvalho

References

Nov 20, 1998·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·V C HeathK H Nicolaides
Nov 21, 2000·American Journal of Obstetrics and Gynecology·E R GuzmanA M Vintzileos
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jun 2, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J L GibsonF Mackenzie
Jul 23, 2005·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L SperlingA Tabor
Mar 4, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·B ArabinJ van Eyck
May 2, 2006·American Journal of Obstetrics and Gynecology·Meekai S ToKypros H Nicolaides
Jun 21, 2007·BMC Pregnancy and Childbirth·Arianne C LimUNKNOWN AMPHIA study group
Aug 2, 2007·Obstetrics and Gynecology·Vincenzo BerghellaJason K Baxter
Oct 3, 2008·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Katharina KleinElisabeth Krampl
Oct 23, 2009·American Journal of Obstetrics and Gynecology·Nathan S FoxDaniel H Saltzman
Jul 16, 2010·Journal of Perinatal Medicine·Carolina HofmeisterMarcelo Zugaib
Apr 6, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A C LimB W J Mol
Nov 3, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R M EhsanipoorD A Wing
Apr 6, 2012·Lancet·Maria GoyaUNKNOWN Pesario Cervical para Evitar Prematuridad (PECEP) Trial Group
Sep 26, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A C LimH W Bruinse
Jan 23, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·C SauvanaudF Sergent
Apr 6, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nesa AsnafiSarah Dadvar
Jun 3, 2014·American Journal of Obstetrics and Gynecology·Ananda BoyerLuis F Goncalves
Aug 26, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·E SchuitUNKNOWN Global Obstetrics Network (GONet) collaboration
Mar 4, 2015·American Journal of Obstetrics and Gynecology·Maria L BrizotMarcelo Zugaib

❮ Previous
Next ❯

Citations

Feb 26, 2016·Seminars in Fetal & Neonatal Medicine·B KoullaliE Pajkrt
Jul 23, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R RomeroS S Hassan
Jan 10, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R RomeroK H Nicolaides
Sep 26, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ashley E HesterBaha M Sibai
Aug 23, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K D LeV Q Dang
Jul 17, 2018·The Obstetrician & Gynaecologist : the Journal for Continuing Professional Development From the Royal College of Obstetricians & Gynaecologists·Sarah R MurrayJane E Norman
Sep 6, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·S MarleenS Thangaratinam
Nov 26, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·César MellerLucas Otaño
Jun 28, 2020·American Journal of Obstetrics and Gynecology·Amanda RomanVincenzo Berghella
Jun 9, 2019·Seminars in Perinatology·Lindsay M Kindinger, Anna L David
Sep 4, 2021·Acta Obstetricia Et Gynecologica Scandinavica·Georgina D FreegardLawrence W M Impey
Sep 28, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·César MellerLucas Otaño
Nov 23, 2021·American Journal of Obstetrics & Gynecology MFM·Amanda RomanNathan S Fox

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.