The Effect of Glatiramer Acetate on Retinal Nerve Fiber Layer Thickness in Patients with Relapsing-Remitting Multiple Sclerosis: A Longitudinal Optical Coherence Tomography Study.

CNS Drugs
Robert ZivadinovBianca Weinstock-Guttman

Abstract

Optical coherence tomography (OCT) is a technique that allows for the assessment of retinal nerve fiber layer thickness (RNFLT) and total macular volume (TMV), which reflect neuroaxonal integrity within the retina. As such it has been used in multiple sclerosis (MS) to study neurodegeneration. Glatiramer acetate (GA) is a widely used treatment for MS, which is suggested to have a possible neuroprotective role. The aim of this study was to assess RFNLT and TMV changes in relapsing-remitting MS (RRMS) patients who started treatment with GA and were followed for a 24-month period. A cohort of 60 RRMS patients and 40 healthy controls (HCs) were imaged with OCT at baseline and follow-up. All subjects also underwent clinical and neurological examination. Measurements were compared between the RRMS patients and HCs as well as between optic neuritis (ON)-affected and ON-unaffected eyes. At baseline, MS patients showed lower average RNFLT (p = 0.046) and TMV (p = 0.013) when compared with HCs. No significant differences in the evolution of OCT measures were detected over the follow-up between MS patients and HCs. MS patients with both affected and unaffected eyes showed significantly lower average RNFLT, temporal inferior RNFLT, and TMV...Continue Reading

References

Sep 1, 1999·Multiple Sclerosis : Clinical and Laboratory Research·F Barkhof
Dec 3, 2005·Multiple Sclerosis : Clinical and Laboratory Research·Omar KhanRobert Lisak
Dec 7, 2007·Journal of the Neurological Sciences·Erica GrazioliMurali Ramanathan
Jun 25, 2008·Multiple Sclerosis : Clinical and Laboratory Research·J ToledoP Villoslada
Jun 1, 2010·Pathophysiology : the Official Journal of the International Society for Pathophysiology·R ZivadinovB Weinstock-Guttman
Jun 10, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Stephanie B SycPeter A Calabresi
Feb 9, 2011·Multiple Sclerosis : Clinical and Laboratory Research·E Garcia-MartinF J Fernandez
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Jul 26, 2011·The British Journal of Ophthalmology·Elena Garcia-MartinJavier Fernandez
Mar 27, 2012·Journal of Neurology·Kerstin HackmackJohn-Dylan Haynes
Apr 27, 2012·PloS One·Prejaas TewarieAxel Petzold
Apr 17, 2013·Journal of Neurology·Douglas L ArnoldSamson Antel
May 21, 2013·Annals of Neurology·Omar KhanUNKNOWN GALA Study Group
May 2, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R ZivadinovM Ramanathan
Jul 21, 2015·Annals of Neurology·Shiv SaidhaPeter A Calabresi
Apr 23, 2016·Expert Review of Neurotherapeutics·Robert ZivadinovNiels Bergsland
May 4, 2016·Expert Review of Neurotherapeutics·Sahil GuptaBianca Weinstock-Guttman
May 5, 2016·Journal of Neurology·Lisanne J BalkAri J Green
May 27, 2016·Neurology·Andrés Cruz-HerranzUNKNOWN IMSVISUAL consortium
Aug 22, 2016·Journal of Neurology·Nabil K El AyoubiSamia J Khoury
Apr 5, 2017·Current Treatment Options in Neurology·Alexander U BrandtShiv Saidha
Apr 11, 2017·Neuroimaging Clinics of North America·Massimo FilippiMaria A Rocca
Jun 24, 2017·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Michela SpadaroAntonio Bertolotto
Sep 19, 2017·Lancet Neurology·Axel PetzoldUNKNOWN ERN-EYE IMSVISUAL

❮ Previous
Next ❯

Citations

Apr 21, 2020·Expert Review of Neurotherapeutics·Eleonora TavazziNiels Bergsland
Feb 12, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Jillian K ChanAnthony Traboulsee
Feb 19, 2021·Neurology. Neuroimmunology and Neuroinflammation·Yuyi YouAlexander Klistorner
Apr 9, 2021·Neurology·Jeffrey LambeShiv Saidha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.