Dec 6, 2005

The effect of global hypoxia on myocardial function after successful cardiopulmonary resuscitation in a laboratory model

Resuscitation
Conán McCaulBrian P Kavanagh

Abstract

Most laboratory studies of cardiac arrest use models of ventricular fibrillation, but in the emergency room, operating room or intensive care unit, cardiac arrest frequently results from asphyxia. We sought to investigate the effect of different durations of asystole secondary to asphyxia on myocardial function after resuscitation. In a laboratory based experimental series, anaesthetized rats received either 4 or 8 min of asphyxial cardiac arrest, and following standardized resuscitation, serial transthoracic echocardiography was performed. Severe depression of left ventricular fractional shortening occurred in both groups with partial recovery only in the 4-min arrest group, while left ventricular end-diastolic diameter was increased in the 4-min group. The pH, HCO3(-) and SBE were reduced in both groups after resuscitation, but the degree of acidosis was greater in the 8-min group. In this model, transthoracic echocardiography demonstrated both systolic and diastolic impairment following asphyxial cardiac arrest, and a clear dose-effect relationship between duration of asphyxia and degree of impairment. A shorter duration of asphyxia was associated with a lesser increase in left ventricular end-diastolic dimension, compared w...Continue Reading

Mentioned in this Paper

Arterial Pulse Pressure
Tracheostomy Route of Drug Administration
Ventricular Fibrillation
Fluctuation
Laboratory Studies
Transthoracic Echocardiography
Lung
Bradycardia
Mitral Valve
Diastolic Blood Pressure

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