The effect of glucocorticoids on the anxiolytic efficacy of buspirone

Psychopharmacology
J HallerG B Makara

Abstract

The serotonergic system and the hypothalamus-hypophysis-adrenocortical axis reciprocally influence each other. Therefore, the interaction between stress and serotonergic anxiolytics should be of major concern for both laboratory investigations and clinical treatment. We have studied the effects of the serotonergic anxiolytic buspirone in rats in which basal levels of glucocorticoids were low and stable, while acute stress reactions were inhibited or exogenously induced. Rats were adrenalectomised. Subcutaneous corticosterone pellets maintained basal glucocorticoid concentrations while acute changes were mimicked by corticosterone injections. Anxiety was assessed by the social interaction test. Temporal changes were evaluated by submitting rats to the same manipulations three times at two-day intervals. Buspirone applied to animals with stable and low plasma glucocorticoid concentrations induced a dramatic increase in social interactions. A slight locomotor suppressive effect was also noticed. The effects of buspirone proved to be stable over time in these animals. Acute treatment with corticosterone doubled the locomotor suppressive effects of buspirone and reversed its anxiolytic effects: the buspirone-corticosterone combinati...Continue Reading

Citations

Dec 9, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eszter MajercsikRobert John Rodgers
Nov 7, 2002·Physiology & Behavior·J Haller, N Bakos
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Nov 26, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Markus StorvikJari Tiihonen
Apr 16, 2010·Stress : the International Journal on the Biology of Stress·Boglárka BarsyJózsef Haller
Dec 22, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eszter Majercsik, József Haller
Aug 9, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jozsef HallerNikoletta Bakos

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