The effect of glutamine supplementation on hematopoietic stem cell transplant outcome in children: a case-control study

Pediatric Transplantation
Baris KuskonmazDuygu Uckan

Abstract

HSCT associated morbidity and mortality is usually attributed to high-dose chemotherapy/radiotherapy regimens used for conditioning. Glutamine (Gln), a conditionally essential amino acid during severe catabolic states, has been shown to have favorable effects in patients with malignancies and in those undergoing HSCT. However, controversy exists regarding its routine use. Studies in children investigating gln supplementation are very limited. In the present study, including 21 gln-supplemented and 20 control pediatric patients, gln supplementation was shown to reduce the duration of fever and decrease the incidence of SOS during the HSCT course. In addition, a decrease in drug-related toxicity and a trend toward reduced incidence of severe mucositis were observed.

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Citations

Jun 15, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Noam YaromUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Dec 17, 2011·Journal of Nutrition and Metabolism·Elise Mok, Régis Hankard
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Jul 10, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Noam YaromUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology
Jul 1, 2011·Experimental and Therapeutic Medicine·Gamze Akbulut
Feb 22, 2013·Journal of Pediatric Hematology/oncology·Zuhal K YildirimMustafa Buyukavci
Nov 7, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Wanessa Miranda-SilvaUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society for Oral Oncolog

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