The Effect of Glyphosate on Human Sperm Motility and Sperm DNA Fragmentation

International Journal of Environmental Research and Public Health
George AnifandisAlexandros Daponte

Abstract

Glyphosate is the active ingredient of Roundup®, which is one of the most popular herbicides worldwide. Although many studies have focused on the reproductive toxicity of glyphosate or glyphosate-based herbicides, the majority of them have concluded that the effect of the specific herbicide is negligible, while only a few studies indicate the male reproductive toxicity of glyphosate alone. The aim of the present study was to investigate the effect of 0.36 mg/L glyphosate on sperm motility and sperm DNA fragmentation (SDF). Thirty healthy men volunteered to undergo semen analysis for the purpose of the study. Sperm motility was calculated according to WHO 2010 guidelines at collection time (zero time) and 1 h post-treatment with glyphosate. Sperm DNA fragmentation was evaluated with Halosperm® G2 kit for both the control and glyphosate-treated sperm samples. Sperm progressive motility of glyphosate-treated samples was significantly reduced after 1 h post-treatment in comparison to the respective controls, in contrast to the SDF of glyphosate-treated samples, which was comparable to the respective controls. Conclusively, under these in vitro conditions, at high concentrations that greatly exceed environmental exposures, glyphosat...Continue Reading

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Citations

Sep 11, 2019·Nutrients·Natalia AndújarAnd Ana Rivas
Jul 28, 2018·International Journal of Environmental Research and Public Health·Yongsheng FanChunhong Wang
Oct 21, 2020·International Journal of Environmental Research and Public Health·Simranjeet SinghJoginder Singh
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Aug 28, 2021·Antioxidants·Maria Nunzia De LucaVittorio Unfer
Nov 28, 2021·International Journal of Molecular Sciences·Marianna MarinoAntonietta Santoro

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