PMID: 3756476Aug 20, 1986Paper

The effect of GM1 ganglioside on coerulospinal, noradrenergic, adult neurons and on fetal monoaminergic neurons transplanted into the transected spinal cord of the adult rat

Brain Research
J W Commissiong, G Toffano

Abstract

GM1 ganglioside, thyroxine and hydrocortisone were tested for their ability to improve the survival and growth of fetal locus coeruleus noradrenergic neurons in the transected, adult spinal cord. GM1 alone was also tested for its effect on fetal mesencephalic dopaminergic neurons implanted into a small dorsolateral cavity at the L2 region of the cord previously transected at the T9-T10 region. None of the substances tested had any measurable effect on either of the fetal implants. However, in the GM1- and thyroxine-treated animals the somatic dendrites of the axotomized, noradrenergic, coerulospinal neurons appeared more robust, and more intensely fluorescent, compared to their appropriate controls. GM1 also caused a pronounced sprouting of the axotomized monoaminergic (catecholaminergic and serotonergic) fibres in the rostral region of the cord adjacent to the transection site. All of the mesencephalic dopaminergic implants survived in both the GM1-treated animals and their saline-injected controls. However, their development was apparently not influenced by GM1. The results indicate that GM1 and thyroxine can enhance those aspects of the reactive mechanisms of mature, axotomized, noradrenergic coerulospinal neurons that promo...Continue Reading

References

Oct 1, 1971·The Journal of Infectious Diseases·W E Van HeyningenW B Greenough

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Citations

Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·J W Commissiong, Y Sauvé
Jul 1, 1991·Brain Research Bulletin·J W CommissiongG Toffano
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L MarlierA Privat
Oct 1, 1990·The Journal of Pharmacy and Pharmacology·U CornelliR Cogo
Aug 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·W Young
Apr 1, 1991·Journal of Neurosurgery·F A RoddenB L Bauer
May 15, 1995·The Journal of Comparative Neurology·K E BowenkampA C Granholm

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