The effect of gold nanorods on cell-mediated collagen remodeling.

Nano Letters
Patrick N SiscoEdie C Goldsmith

Abstract

Cardiac fibroblasts, the noncontractile cells of the heart, contribute to myocardial maintenance through the deposition, degradation, and organization of collagen. Adding polyelectrolyte-coated gold nanorods to three-dimensional constructs composed of collagen and cardiac fibroblasts reduced contraction and altered the expression of mRNAs encoding beta-actin, alpha-smooth muscle actin, and collagen type I. These data show that nanomaterials can modulate cell-mediated matrix remodeling and suggest that the targeted delivery of nanomaterials can be applied for antifibrotic therapies.

References

Jul 1, 1993·The Anatomical Record·W CarverT K Borg
Nov 12, 1996·Biochemistry·P G AllenI M Herman
Sep 17, 2002·Current Opinion in Cell Biology·Edna CukiermanKenneth M Yamada
Dec 14, 2002·Circulation Research·Ichiro ManabeRyozo Nagai
Dec 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Huijung KimStephen I Rennard
May 14, 2003·Trends in Cell Biology·Frederick Grinnell
Jul 8, 2003·The Journal of Pathology·G Gabbiani
Sep 13, 2003·Nature Materials·Aliasger K SalemKam W Leong
Oct 2, 2003·Nature Biotechnology·Vicki L Colvin
Apr 14, 2005·Chemical Reviews·Nathaniel L Rosi, Chad A Mirkin
Jun 24, 2005·Journal of Biomedical Materials Research. Part a·Rebecca A MacDonaldJan P Stegemann
Apr 13, 2006·Nano Letters·B Devika ChithraniWarren C W Chan
Jul 21, 2006·The Journal of Physical Chemistry. B·Catherine J MurphyTan Li
Jan 11, 2007·Nano Letters·John W StoneCatherine J Murphy
Jul 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Indroneal BanerjeeTroy A Baudino
Jan 1, 2008·Small·Nastassja LewinskiRebekah Drezek
May 1, 2008·Cell Biochemistry and Biophysics·Sarah C BaxterEdie C Goldsmith
Jul 26, 2008·Nature Nanotechnology·Wen JiangWarren C W Chan
Sep 1, 1997·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·K T BorgT K Borg

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Citations

Jul 10, 2009·Chemical Society Reviews·Elodie Boisselier, Didier Astruc
Feb 2, 2011·The Journal of Chemical Physics·Carlos E Román-Velázquez, Cecilia Noguez
Jun 20, 2013·BioMed Research International·Wayne Carver, Edie C Goldsmith
Jun 12, 2013·Trends in Cardiovascular Medicine·James A ShumanFrancis G Spinale
May 25, 2010·Acta Biomaterialia·Martín F DesimoneThibaud Coradin
Aug 4, 2009·Biomaterials·Christopher G WilsonEdie C Goldsmith
Feb 23, 2012·Scientific Reports·Palanisamy ThanikaivelanPulickel M Ajayan
Jan 22, 2013·Life Sciences·Vennece FowlkesEdie C Goldsmith
Sep 1, 2012·Journal of the American Chemical Society·Samuel E Lohse, Catherine J Murphy
Jun 14, 2011·Nanomaterials·Pooja M TiwariShree R Singh
Oct 23, 2019·Drug Delivery and Translational Research·Ghada AlomariMurtaza M Tambuwala
Nov 13, 2014·Nanoscale·Dakrong Pissuwan, Takuro Niidome
Jul 4, 2013·Biomaterials Science·Sascha HeinemannMartin F Desimone
Mar 24, 2017·Advanced Functional Materials·Kai ZhuAli Khademhosseini
May 14, 2021·Advanced Drug Delivery Reviews·Fabiana PassaroGianluca Testa

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