The effect of graded hemorrhage and intravascular volume replacement on systolic pressure variation in humans during mechanical and spontaneous ventilation

Anesthesia and Analgesia
G A RookeY Shapira

Abstract

In dogs and humans, the magnitude of the variation in systolic pressure (SPV) over the respiratory cycle during mechanical ventilation appears to be inversely related to intravascular volume. Also reported to correlate with changes in volume status is delta down, the difference between systolic pressure at end-expiration and the lowest value during the respiratory cycle. These variables were examined during graded hemorrhage in eight anesthetized, mechanically ventilated subjects, and seven awake, spontaneously breathing subjects. SPV and delta down were measured in sequence at baseline, after 500 mL blood removal, after 1000 mL (total) blood removal, after 500 mL hetastarch replacement, after 1000 mL (total) hetastarch replacement, and after 500 mL normal saline (NS). Repeated-measures analysis of variance was used to test the significance of the change in SPV and delta down among the interventions. During mechanical ventilation, each 500-mL hemorrhage significantly increased SPV and delta down, and each 500-mL hetastarch infusion significantly decreased SPV and delta down. After hetastarch, both SPV and delta down were smaller than at baseline and may explain why the infusion of NS caused nonsignificant reductions in SPV and ...Continue Reading

References

Aug 30, 1979·The New England Journal of Medicine·A J BudaE L Alderman
Feb 12, 1986·The American Journal of Cardiology·J L Fleg
Jan 1, 1987·Circulation·T K NatarajanH N Wagner
Nov 1, 1967·The Journal of Clinical Investigation·J N CohnF E Tristani
Oct 1, 1983·Critical Care Medicine·J L RobothamB Bromberger-Barnea
Aug 1, 1983·Circulation·F JardinJ P Bourdarias
Aug 1, 1982·Respiration Physiology·F M Bennett, S M Tenney
Apr 1, 1993·Anaesthesia·D J Bihari, R W Chang

❮ Previous
Next ❯

Citations

Dec 6, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jihad MallatBenoît Tavernier
Nov 15, 2006·Intensive Care Medicine·Paolo PelosiPierre Asfar
Mar 30, 2004·Autonomic Neuroscience : Basic & Clinical·Eva ZölleiLászló Rudas
Apr 3, 1998·Journal of Clinical Anesthesia·E OrnsteinR Pizov
Oct 11, 2005·Critical Care Medicine·Michael R Pinsky
Apr 4, 2013·Current Opinion in Critical Care·Michelle S Chew, Anders Åneman
Jul 26, 2011·Anesthesiology Research and Practice·Sumit SinghGeoffrey Lighthall
Jan 14, 2004·American Journal of Respiratory and Critical Care Medicine·Sheldon Magder
May 22, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rupert M PearseJohn Barry
Jul 19, 2006·Critical Care : the Official Journal of the Critical Care Forum·Sarah HeenenJean-Louis Vincent
Sep 20, 2006·Critical Care : the Official Journal of the Critical Care Forum·S Magder
Nov 30, 2000·Critical Care : the Official Journal of the Critical Care Forum·F Michard, J L Teboul
Jun 26, 2010·Critical Care : the Official Journal of the Critical Care Forum·Fritz DaudelJukka Takala
Dec 7, 2014·Best Practice & Research. Clinical Anaesthesiology·Stephen A Esper, Michael R Pinsky
Aug 19, 2007·Journal of Clinical Monitoring and Computing·Michael J GesquiereKirk H Shelley
Oct 9, 2008·Journal of Clinical Monitoring and Computing·Matteo ZaniboniGaetano Iapichino
Jan 15, 2015·The American Journal of the Medical Sciences·Erwin ArguetaKenneth M Nugent
Oct 27, 2015·Acta Anaesthesiologica Scandinavica·E KjetsåI Kirkeby-Garstad
Oct 2, 2012·Surgical Oncology Clinics of North America·Kenneth P Rothfield, Kathy Crowley
May 15, 2007·Chest·Matthias EikermannAtul Malhotra
Jan 11, 2013·Kidney International·Kambiz KalantariMitchell H Rosner
Jul 20, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Koichi Suehiro, Ryu Okutani
Jun 16, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·M CannessonJ-J Lehot
Oct 15, 2009·Anesthesiology Clinics·Alexander A Vitin, Julia I Metzner
Mar 9, 2007·Anesthesiology Clinics·Atilio Barbeito, Jonathan B Mark
Nov 23, 2006·The Surgical Clinics of North America·Kristen C Sihler, Avery B Nathens
Dec 14, 2004·Journal of Clinical Anesthesia·Christopher R TurnerPema Dorje
Jan 22, 2003·Intensive Care Medicine·Karim Bendjelid, Jacques-A Romand
Aug 4, 2016·Journal of Clinical Monitoring and Computing·Kavita YadavK K Deepak
Feb 10, 2011·Anesthesia and Analgesia·Micha Y ShamirYoram Klein
May 31, 2014·Seminars in Cardiothoracic and Vascular Anesthesia·Geoffrey Kenton Lighthall, Sumit Singh
Jun 11, 2002·International Anesthesiology Clinics·Lorri A LeeArthur M Lam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.