PMID: 11334279May 4, 2001Paper

The effect of groups II and III metabotropic glutamate receptor activation on neuronal injury in a rodent model of traumatic brain injury

Neurosurgery
M ZwienenbergBruce G Lyeth

Abstract

The role of metabotropic glutamate receptor activation after traumatic brain injury (TBI) is not well understood. In vitro studies suggest that activation of Groups II and III metabotropic glutamate receptors may provide some degree of neuroprotection and may be potential targets for the development of therapeutic strategies. Thus, we examined the effects of Group II and Group III selective agonists on neuronal degeneration after in vivo TBI. Fifty male Sprague-Dawley rats were subjected to lateral fluid percussion brain injury immediately followed by an intracranial injection of 2-(2',3')-dicarboxycyclopropylglycine (DCG-IV) (Group II) or (R,S)-4-phosphonophenylglycine (Group III) in the CA2 and CA3 areas of the hippocampus. DCG-IV was injected at doses of 20 fmol, 100 fmol, and 500 fmol, and (R,S)-4-phosphonophenylglycine was injected at 8 nmol, 40 nmol, and 200 nmol. Vehicle injection control groups were used for comparison with each drug group. All animals were killed 24 hours after TBI was induced. Four 50-microm brain sections were obtained from each animal and stained for degenerating neurons with the fluorochrome Fluoro-Jade. Two independent, blinded investigators counted the number of degenerating (Fluoro-Jade-positive...Continue Reading

References

Jan 1, 1992·Neuron·Y TanabeS Nakanishi
Jan 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T KawamataD P Becker
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P NilssonU Ungerstedt
Jul 1, 1987·Journal of Neurosurgery·C E DixonR L Hayes
Jan 1, 1995·Neuropharmacology·J P Pin, R Duvoisin
Jan 1, 1996·Pharmacology & Toxicology·A I Faden
Jan 1, 1996·The European Journal of Neuroscience·A BuissonD W Choi
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·P J Conn, J P Pin
Dec 31, 1997·Journal of Neurotrauma·D H SmithT K McIntosh
Feb 25, 1998·Journal of Neurotrauma·A I FadenA G Mukhin
Oct 26, 1999·Neuropharmacology·D D SchoeppJ A Monn
Feb 11, 2000·Toxicologic Pathology·L C Schmued, K J Hopkins

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Citations

Jan 25, 2005·Journal of Neurotrauma·Hilaire J ThompsonTracy K McIntosh
Jan 19, 2006·Journal of Neurochemistry·Leah J SartoriusPaul J Harrison
Nov 19, 2011·Journal of Neurogenetics·Brice CampoSylvain Celanire
May 3, 2011·Annual Review of Biomedical Engineering·Barclay MorrisonMartin L Yarmush

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