PMID: 6113566Nov 1, 1980Paper

The effect of H1-blocking antihistamines on intraocular pressure in rabbits

Ophthalmology
T KrupinB Becker

Abstract

H1-blocking antihistamines were administered topically to rabbits to determine their effects on intraocular pressure. Chlorcyclizine which is in the piperazine class of H1-inhibitors was found to elevate intraocular pressure. This effect was prevented by the systemic administration of indomethacin and is probably a prostaglandin induced change. Of the other agents tested, antazoline which is in the ethylenediamine class, was the only drug found to lower intraocular pressure. The antazoline-induced lowering of intraocular pressure was associated with no changes in outflow facility, episcleral venous pressure, systemic blood pressure, or ocular blood flow. Tonographic and aqueous humor ascorbate humor ascorbate data suggested a decreased (41% and 33% respectively) rate of aqueous flow as the mechanism for the decrease in intraocular pressure. The systemic administration of the alpha-adrenergic blocker phentolamine prevented the decrease in intraocular pressure but systemically administered blockers of cholinergic (atropine) or beta-adrenergic (propranolol) activity had no effect.

References

Jan 1, 1976·Drugs·D S Pearlman
Aug 1, 1966·British Journal of Pharmacology and Chemotherapy·A S Ash, H O Schild
Apr 21, 1972·Nature·J W BlackE M Parsons
Dec 1, 1973·American Journal of Ophthalmology·T KrupinB Becker
Mar 1, 1955·A.M.A. Archives of Ophthalmology·V E KINSEY, E PALM
May 1, 1949·Current Researches in Anesthesia & Analgesia·F F YONKMANN, F ROTH
Sep 1, 1949·British Journal of Pharmacology and Chemotherapy·N K DUTTA
Mar 1, 1934·The British Journal of Ophthalmology·B W Rycroft

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Citations

Jan 1, 1989·Pharmacology & Therapeutics·M F Sugrue
Jan 10, 2003·Psychiatry and Clinical Neurosciences·Chi-Un PaeIn-Ho Paik

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