The effect of H3 O+ on the membrane morphology and hydrogen bonding of a phospholipid bilayer

Biophysics Reviews
Evelyne DeplazesCharles G Cranfield

Abstract

At the 2017 meeting of the Australian Society for Biophysics, we presented the combined results from two recent studies showing how hydronium ions (H3O+) modulate the structure and ion permeability of phospholipid bilayers. In the first study, the impact of H3O+ on lipid packing had been identified using tethered bilayer lipid membranes in conjunction with electrical impedance spectroscopy and neutron reflectometry. The increased presence of H3O+ (i.e. lower pH) led to a significant reduction in membrane conductivity and increased membrane thickness. A first-order explanation for the effect was assigned to alterations in the steric packing of the membrane lipids. Changes in packing were described by a critical packing parameter (CPP) related to the interfacial area and volume and shape of the membrane lipids. We proposed that increasing the concentraton of H3O+ resulted in stronger hydrogen bonding between the phosphate oxygens at the water-lipid interface leading to a reduced area per lipid and slightly increased membrane thickness. At the meeting, a molecular model for these pH effects based on the result of our second study was presented. Multiple μs-long, unrestrained molecular dynamic (MD) simulations of a phosphatidylchol...Continue Reading

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Citations

Mar 29, 2020·Science China Materials·Congcong CuiLu Han
Mar 26, 2021·Journal of Colloid and Interface Science·Vitalii I Silin, David P Hoogerheide

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Methods Mentioned

BETA
neutron diffraction

Software Mentioned

GROMOS
GROMACS

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