The effect of haemorrhagic shock and resuscitation on fracture healing in a rabbit model: an animal study

The Bone & Joint Journal
J BradyZ J Balogh

Abstract

Little is known about the effect of haemorrhagic shock and resuscitation on fracture healing. This study used a rabbit model with a femoral osteotomy and fixation to examine this relationship. A total of 18 male New Zealand white rabbits underwent femoral osteotomy with intramedullary fixation with 'shock' (n = 9) and control (n = 9) groups. Shock was induced in the study group by removal of 35% of the total blood volume 45 minutes before resuscitation with blood and crystalloid. Fracture healing was monitored for eight weeks using serum markers of healing and radiographs. Four animals were excluded due to postoperative complications. The serum concentration of osteocalcin was significantly elevated in the shock group postoperatively (p < 0.0001). There were otherwise no differences with regard to serum markers of bone healing. The callus index was consistently increased in the shock group on anteroposterior (p = 0.0069) and lateral (p = 0.0165) radiographs from three weeks postoperatively. The control group showed an earlier decrease of callus index. Radiographic scores were significantly greater in the control group (p = 0.0025). In a rabbit femoral osteotomy model with intramedullary fixation, haemorrhagic shock and resuscit...Continue Reading

References

Aug 1, 1987·The Journal of Bone and Joint Surgery. British Volume·R F Spencer
Apr 1, 1967·The Journal of Physiology·J P ChalmersS W White
May 1, 1993·Bone and Mineral·J NapalJ González-Macías
May 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K D JohnsonM F Sciadini
Apr 3, 2002·Journal of Orthopaedic Trauma·Adam J StarrHong Zhang
Sep 19, 2003·Langenbeck's Archives of Surgery·Mark BumannPeter Augat
Oct 8, 2004·Critical Care : the Official Journal of the Critical Care Forum·Guillermo GutierrezMarian E Wulf-Gutierrez
Mar 2, 2010·The Journal of Bone and Joint Surgery. British Volume·G CoxP V Giannoudis
Feb 2, 2012·Nature Reviews. Rheumatology·Lutz ClaesAnita Ignatius
Jan 25, 2013·Journal of Orthopaedic Trauma·Krisztian SisakZsolt J Balogh
Jun 19, 2013·Seminars in Immunology·Markus Huber-LangAnita Ignatius
Jun 25, 2015·Mediators of Inflammation·Philipp LichteThomas Pufe
Sep 12, 2017·European Cells & Materials·O YoshinoZ J Balogh

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Citations

Aug 17, 2020·JBJS Reviews·Justin E HellwinkelZachary M Working

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Methods Mentioned

BETA
dissection

Software Mentioned

SPSS
AMICAS
GraphPad Prism

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