The effect of heating rate on the cutaneous vasomotion responses of forearm and leg skin in humans

Microvascular Research
Andrew T Del PozziGary J Hodges

Abstract

We examined skin blood flow (SkBF) and vasomotion in the forearm and leg using laser-Doppler fluxmetry (LDF) and spectral analysis to investigate endothelial, sympathetic, and myogenic activities in response to slow (0.1 °C·10 s(-1)) and fast (0.5 °C·10 s(-1)) local heating. At 33 °C (thermoneutral) endothelial activity was higher in the legs than the forearms (P ≤ 0.02). Fast-heating increased SkBF more than slow heating (P=0.037 forearm; P=0.002 leg). At onset of 42 °C, endothelial (P=0.043 forearm; P=0.48 leg) activity increased in both regions during the fast-heating protocol. Following prolonged heating (42 °C) endothelial activity was higher in both the forearm (P=0.002) and leg (P<0.001) following fast-heating. These results confirm regional differences in the response to local heating and suggest that the greater increase in SkBF in response to fast local heating is initially due to increased endothelial and sympathetic activity. Furthermore, with sustained local skin heating, greater vasodilatation was observed with fast heating compared to slow heating. These data indicate that this difference is due to greater endothelial activity following fast heating compared to slow heating, suggesting that the rate of skin heati...Continue Reading

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Citations

Jan 10, 2017·Microvascular Research·Matthew M MalletteStephen S Cheung
May 19, 2017·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·N SettembreM Venermo
Jan 13, 2017·Physiological Measurement·Michele SorelliLeonardo Bocchi
Apr 2, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Gary J HodgesStephen S Cheung
Jul 9, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K ReminyS Antoine-Jonville
Sep 25, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huan OuyangXiaolei Wang
Jun 20, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Gary J HodgesAndrew T Del Pozzi
Jan 6, 2021·Lasers in Medical Science·Claudia Maria Duarte de Sá
Feb 16, 2021·Applied Microbiology and Biotechnology·Bouke BoekemaEsther Middelkoop
Aug 30, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Irina V TikhonovaArina V Tankanag
Nov 11, 2021·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Ingemar FredrikssonFredrik Iredahl

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