The effect of Helicobacter pylori eradication therapy on the development of gastroesophageal reflux disease

The American Journal of the Medical Sciences
Jiacheng TanLin Lin

Abstract

It is uncertain whether the Helicobacter pylori eradication therapy makes a role in the progression of gastroesophageal reflux disease (GERD). A meta-analysis was undertaken to investigate the effect of H pylori eradication therapy on the development of GERD. Overall, 16 cohort studies were included. The authors demonstrated that H pylori eradication had no significant effect on the occurrence of GERD in these cohort studies (odds ratio = 0.87, 95% confidence interval = 0.66-1.14, I = 32.4%, P = 0.103). In general, H pylori eradication has no significant effect on the development of GERD in the long term. However, eradication therapy should be taken once there is H pylori infection, because H pylori infection is acknowledged to be a major cause of acute and chronic gastritis and peptic ulcer diseases and has been established as a definite etiologic factor for gastric cancer.

References

Feb 7, 1994·NIH Consensus Statement
Sep 16, 1998·Journal of Gastroenterology and Hepatology·R H Hunt, S K Lam
Jun 26, 1999·Alimentary Pharmacology & Therapeutics·S TeferaA Berstad
Dec 11, 1999·Carcinogenesis·C T Stadtländer, J W Waterbor
Aug 5, 2003·Alimentary Pharmacology & Therapeutics·F CremoniniM Camilleri
May 18, 2005·The Journal of Infectious Diseases·Abraham M Y NomuraMartin J Blaser
Jul 19, 2011·Helicobacter·Bingbing QianGuoxin Zhang
Apr 12, 2012·Gut·Peter MalfertheinerUNKNOWN European Helicobacter Study Group
Sep 27, 2012·Digestive Diseases and Sciences·Hassan AshktorabHadie Razjouyan

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Citations

Sep 16, 2015·Helicobacter·Georgios S Potamitis, Anthony T R Axon
Dec 29, 2016·Digestive Diseases and Sciences·Rena YadlapatiRajesh N Keswani
Aug 29, 2018·Esophagus : Official Journal of the Japan Esophageal Society·Oya Yucel
Jul 18, 2015·World Journal of Gastroenterology : WJG·Takao MaekitaMasao Ichinose
Nov 3, 2016·Cancer Prevention Research·John Maret-OudaJesper Lagergren
Jun 3, 2021·Cancers·Elisa MarabottoEdoardo Savarino

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