The Effect of Hematocrit and Nanoparticles Diameter on Hemodynamic Parameters and Drug Delivery in Abdominal Aortic Aneurysm with Consideration of Blood Pulsatile Flow

Computer Methods and Programs in Biomedicine
Sina JafarzadehArash Karimipour

Abstract

The present article has simulated to investigate the efficient hemodynamic parameters, the drug persistence, and drug distribution on an abdominal aortic aneurysm. Blood as a non-Newtonian fluid enters the artery acting as a real pulse waveform; its behavior is dependent on hematocrit and strain rate. In this simulation of computational fluid dynamic, magnetic nanoparticles of iron oxide which were in advance coated with the drug, are injected into the artery during a cardiac cycle. A two-phase model was applied to investigate the distribution of these carriers. The results are presented for different hematocrits and the nanoparticle diameter. It is observed that hematocrit significantly affects drug persistence, so that lower hematocrit incites more accumulation of the drug in the dilatation part of the artery. The better drug accumulation is noticed, at the higher wall shear stress. Although no considerable impact on the flow pattern and wall shear stress was found with various nanoparticle diameters, the smaller size of the nanoparticles results in a greater amount of drug augmentation in the aneurysm wall output. At the higher hematocrit levels, the blood resistance to drug delivery increases throughout the artery. Also, th...Continue Reading

Citations

Aug 3, 2021·Rheologica Acta·Pavlos S Stephanou

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