The effect of hemodialysis on accelerated atherosclerosis in diabetic patients: correlation of carotid artery intima-media thickness with oxidative stress

Journal of Diabetes and Its Complications
Belda DursunTomris Ozben

Abstract

Both diabetes and hemodialysis (HD) are associated with increased oxidative stress. The aim of this study was to clarify the effect of maintenance HD on oxidative stress parameters in diabetic patients and to explore any relation between carotid artery intima-media thickness (CIMT) and oxidative stress markers. Twenty Type 2 diabetic patients undergoing chronic maintenance HD, 20 type 2 diabetic patients with normal renal function, and 20 age- and sex-matched healthy subjects were included. Serum thiobarbituric acid reactive substances (TBARS), protein carbonyl content (PCO), and nitrite/nitrate levels were determined as oxidative stress markers. Serum vitamin E, plasma sulfhydryl (P-SH), erythrocyte glutathione (GSH) levels, and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were measured as antioxidants. CIMT was assessed by carotid artery ultrasonography. Both diabetic patient groups had enhanced oxidative stress indicated by higher levels of TBARS, PCO, and nitrate/nitrite and lower activities of SOD, CAT, and GPx compared to controls. Diabetic patients undergoing HD had significantly higher CIMT (P=.001) and higher levels of nitrite/nitrate (P=.05), PCO (P=.03), and GSH (P=.04) but ...Continue Reading

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May 3, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Masahiro NatsuakiTakeshi Kimura
Dec 21, 2013·Journal of Diabetes and Metabolic Disorders·Mona H El SamahyNermeen A Kamal
Jan 1, 2014·Echocardiography·Burak AltunFatma Uysal
Mar 15, 2016·International Heart Journal·Hideki YagiMasami Murakami
Mar 21, 2012·The Journal of International Medical Research·M Yusuf AlsagaffY Tomino
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