The effect of hemorrhagic shock in a caprine tibial fracture model

Journal of Orthopaedic Trauma
Adam StarrHong Zhang

Abstract

The purpose of this study was to assess effects of hemorrhagic shock on fracture healing in a large animal closed fracture model. Prospective randomized trial. University Medical Center. Eight skeletally mature neutered male goats. Standardized bilateral closed midshaft tibia fractures were created in all the goats. The goats were randomized to a hemorrhage, shock and resuscitation group (shock group), or a control group. Hemorrhagic shock was induced in the four goats in the shock group. The shock state was maintained for thirty minutes. The remaining four goats were used as a control group. All fractures were stabilized with a standardized external fixator. Swan-Ganz catheters were used to record cardiac output (CO). Arterial blood was sampled to determine base deficit values for the goats after hemorrhage. Radiographs were obtained weekly. After four weeks the tibias were harvested and nondestructively tested in torsion. Immediately after mechanical testing, the tibias were processed for histologic analysis. Standard histomorphologic indices, including total bone volume (TV/BV%), osteoblast surfaces (Ob/BS%), and osteoid surface (OS/BS%), were measured. One goat in the shock group became agitated upon emergence from anesthes...Continue Reading

References

Sep 1, 1983·The Journal of Trauma·E FaistG Heberer
Mar 14, 1998·The Journal of Trauma·Y X XuI H Chaudry
Sep 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R D WelchX J Li
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Citations

Jun 19, 2013·Injury·Claudia NeunaberFrank Hildebrand
Nov 26, 2015·Journal of Orthopaedic Trauma·Frank HildebrandUNKNOWN Trauma Research Network of the German Society of Trauma, DGU
Jun 25, 2015·Mediators of Inflammation·Philipp LichteThomas Pufe
May 23, 2018·The Journal of Trauma and Acute Care Surgery·Katrin BundkirchenClaudia Neunaber
Jul 19, 2008·Shock·Takeshi Tsukamoto, Hans Christoph Pape
Aug 11, 2017·Clinical Orthopaedics and Related Research·Katrin BundkirchenClaudia Neunaber
Mar 27, 2019·BioMed Research International·Markus RuppMichael J Raschke
Sep 29, 2020·Immunology·Jessica Katy Skelton, Robert Purcell

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