The effect of hepatectomy on coagulation: an evaluation by thromboelastography

European Journal of Gastroenterology & Hepatology
Derya KarakocAhmet Ozenc

Abstract

Liver has a major role in coagulation. The hemostatic derangements measured by the mostly used coagulation parameters as prothrombin time, activated partial thromboplastin time, and thrombocyte count do not always correlate with the bleeding associated with liver diseases and these factors do not measure the thrombotic risks. So, thromboelastography is used in new clinical and laboratory research. The aim of this study is to study the effect of different levels of hepatectomy on coagulation. Laparatomy, 40% hepatectomy, and 70% hepatectomy was performed in three different groups of rats. Prothrombin time, international normalized ratio, activated partial thromboplastin time, thrombocyte count, fibrinogen levels, and thromboelastography parameters were obtained at the 0, 6, and 24th hour of the study. Fibrinogen level at the 24th hour was greater than the early hours in both of the hepatectomy groups. Prothrombin time and international normalized ratio values were significantly higher in hepatectomy groups than in the sham group. There were no statistically significant difference in the clotting time, clot formation time, alpha-angle, and maximum clot firmness values in any of the thromboelastography channels, in any of the stud...Continue Reading

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Citations

Dec 7, 2013·World Journal of Gastroenterology : WJG·Shan JinTu Wuyun
May 15, 2013·Anaesthesia·P TzimasS V Mallett
Jan 22, 2013·Clinical Transplantation·Maged MohammedKoichio Tanaka
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