The effect of hepatectomy on coagulation: an evaluation by thromboelastography

European Journal of Gastroenterology & Hepatology
Derya KarakocAhmet Ozenc


Liver has a major role in coagulation. The hemostatic derangements measured by the mostly used coagulation parameters as prothrombin time, activated partial thromboplastin time, and thrombocyte count do not always correlate with the bleeding associated with liver diseases and these factors do not measure the thrombotic risks. So, thromboelastography is used in new clinical and laboratory research. The aim of this study is to study the effect of different levels of hepatectomy on coagulation. Laparatomy, 40% hepatectomy, and 70% hepatectomy was performed in three different groups of rats. Prothrombin time, international normalized ratio, activated partial thromboplastin time, thrombocyte count, fibrinogen levels, and thromboelastography parameters were obtained at the 0, 6, and 24th hour of the study. Fibrinogen level at the 24th hour was greater than the early hours in both of the hepatectomy groups. Prothrombin time and international normalized ratio values were significantly higher in hepatectomy groups than in the sham group. There were no statistically significant difference in the clotting time, clot formation time, alpha-angle, and maximum clot firmness values in any of the thromboelastography channels, in any of the stud...Continue Reading


Jan 1, 1977·Seminars in Thrombosis and Hemostasis·K LechnerE Thaler
Sep 1, 1987·Anesthesia and Analgesia·K J TumanA D Ivankovich
May 1, 1994·The Medical Clinics of North America·E F Mammen
Jun 24, 1998·Journal of Cardiothoracic and Vascular Anesthesia·E G PivalizzaF S King
Oct 16, 1999·The American Journal of Gastroenterology·Z Ben-AriA K Burroughs
Jun 13, 2000·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·S I Rapaport
Apr 3, 2002·Seminars in Liver Disease·Lucio AmitranoAntonio Balzano
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Elisabetta CeruttiMauro Salizzoni
Mar 1, 2005·Seminars in Cardiothoracic and Vascular Anesthesia·Linda Shore-Lesserson
May 28, 2005·Anesthesia and Analgesia·Douglas J McCrathElliott Bennett-Guerrero
May 28, 2005·The Journal of Trauma·Wenjun Z MartiniJohn B Holcomb
Jun 23, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Abeer K Al GhumlasFaleh Z Al Faleh
Jul 5, 2005·Critical Care Clinics·Jody L Kujovich
Sep 9, 2005·Seminars in Thrombosis and Hemostasis·Hans-Jörg HertfelderClaus J Preusse
Nov 9, 2005·Seminars in Thrombosis and Hemostasis·Christopher O Nessel
Jul 26, 2006·The American Journal of Gastroenterology·Patrick G NorthupCarl L Berg
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephen H CaldwellUNKNOWN Coagulation in Liver Disease Group
Oct 13, 2006·International Anesthesiology Clinics·Yoogoo Kang, Paul Audu
Dec 19, 2006·Transplantation Proceedings·A LambingM S Abouljoud
Dec 29, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Soo Joo ChoiJae Won Joh
Jan 5, 2007·World Journal of Gastroenterology : WJG·M SenzoloA-K Burroughs
May 8, 2007·Journal of the American College of Surgeons·John T MullenJean-Nicolas Vauthey
Jun 27, 2007·Alimentary Pharmacology & Therapeutics·A TripodiA J Sanyal

❮ Previous
Next ❯


Dec 7, 2013·World Journal of Gastroenterology : WJG·Shan JinTu Wuyun
May 15, 2013·Anaesthesia·P TzimasS V Mallett
Jan 22, 2013·Clinical Transplantation·Maged MohammedKoichio Tanaka
Nov 21, 2012·Physiological Research·D RychtrmocZ Červinková

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.