Sep 1, 1977

The effect of hepatitis B on plasma cholesterol and sterol balance

The American Journal of Medicine
C D Saudek

Abstract

A patient with hepatitis B was studied by cholesterol balance technics throughout 29 days of the incubation period, the entire preicteric phase (49 days) and 15 days into the icteric phase. As hepatic inflammation developed, the plasma cholesterol concentration declined, reaching 56 per cent of its base line level before the onset of jaundice. Fecal bile acids diminished slightly whereas fecal neutral steroids were unchanged. As jaundice developed, the plasma cholesterol level rose abruptly and fecal bile acid excretion decreased markedly. This report suggests that plasma cholesterol is diminished by hepatitis prior to the development of icterus. Cholesterol synthesis is probably decreased.

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Mentioned in this Paper

Epicholesterol
Bile Acid Measurement
Yellow Skin or Eyes (Symptom)
Cholesterol Biosynthetic Process
Hepatic
Body Excretions
Excretory Function
Icterus <bird>
Plasma Cholesterol Test
Feces

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