The effect of HF-rTMS over the left DLPFC on stress regulation as measured by cortisol and heart rate variability.

Hormones and Behavior
Matias PulopulosRudi De Raedt

Abstract

The prefrontal cortex, and especially the Dorsolateral Prefrontal Cortex (DLPFC), plays an inhibitory role in the regulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis under stressful situations. Moreover, recent evidence suggests that a sustained DLPFC activation is associated with adaptive stress regulation in anticipation of a stressful event, leading to a reduced stress-induced amygdala response, and facilitating the confrontation with the stressor. However, studies using experimental manipulation of the activity of the DLPFC before a stressor are scarce, and more research is needed to understand the specific role of this brain area in the stress-induced physiological response. This pre-registered study investigated the effect on stress regulation of a single excitatory high frequency (versus sham) repetitive transcranial magnetic stimulation (HF-rTMS) session over the left DLPFC applied before the Trier Social Stress Test in 75 healthy young women (M = 21.05, SD = 2.60). Heart rate variability (HRV) and salivary cortisol were assessed throughout the experimental protocol. The active HF-rTMS and the sham group showed a similar cognitive appraisal of the stress task. No differences in HRV were observed during both the ...Continue Reading

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Citations

Sep 13, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yuta YoshinoYogesh Dwivedi
Mar 17, 2021·Psychophysiology·Julian F ThayerJulian Koenig
Mar 28, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Stefanie De SmetMarie-Anne Vanderhasselt
May 28, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Blair T CrewtherRafał Rola

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