The effect of high-calorie diet on nutritional parameters of children with beta-thalassaemia major

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Ashraf T SolimanM Alaa Thabet

Abstract

Impaired growth accompanying thalassaemia major poses diagnostic and therapeutic problems. To test the hypothesis that impaired growth of children with thalassaemia major might be corrected, partially or totally, by increasing their caloric intake. In a prospective controlled study, thirty selected children with thalassaemia major and 30 normal age and sex-matched controls were recruited. The dietary intake of both groups was evaluated. Nutritional status was assessed by measuring the weight, body mass index (BMI), mid-arm circumference (MAC), triceps skin fold thickness (SFT) and serum albumin and insulin-like growth factor-I (IGF-I) concentrations. The thalassaemic group was then, randomly divided into two equal groups. One group was given 8 weeks of high-caloric diet (130-150% of the caloric recommendation for age and sex) and the other was given the normal caloric requirement. Initially the BMI, triceps SFT and MAC of children with thalassaemia were significantly decreased compared to those for the normal control group. IGF-I and albumin concentrations of thalassemic children before nutritional supplementation (69 +/- 20.5 ng/m and 3.65 +/- 0.67 g/dl, respectively) were significantly lower than those for normal age and sex-...Continue Reading

Citations

Mar 3, 2015·Indian Journal of Endocrinology and Metabolism·Ashraf T SolimanMohamed Yassin
Aug 18, 2010·Annals of the New York Academy of Sciences·Ellen B Fung
Dec 17, 2009·Hemoglobin·Ashraf T SolimanRasha Ashour
Jan 30, 2016·Annals of the New York Academy of Sciences·Ellen B Fung
May 28, 2015·The Cochrane Database of Systematic Reviews·Damian K FrancisRuth M Watling
Jan 14, 2020·Journal of Pediatric Hematology/oncology·Mohsen S ElalfyAmna S A Kalifa
Jul 23, 2015·Journal of Pediatric Hematology/oncology·Venée N TubmanUNKNOWN Thalassemia Clinical Research Network
Jun 16, 2010·The Journal of Pediatrics·Ellen B FungUNKNOWN Thalassemia Clinical Research Network

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