PMID: 7538312Jan 1, 1995Paper

The effect of "high dose" aprotinin and other factors on bleeding and revisions for bleeding in adult coronary and valve operations: an analysis of 2190 patients during a five-year period (1987-1991)

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
A ParolariP Biglioli

Abstract

We retrospectively evaluated risk factors for postoperative bleeding and for revisions due to bleeding in 2190 adult coronary and valve patients who underwent surgery at our hospital during the 5-year period from 1987 to 1991. During this period 889 (40.6%) patients were given "high dose" aprotinin. Their mean age was 59.3 +/- 8.8 years, 1636 (74.7%) were males, 200 (9.1%) underwent surgery on an emergency basis and 72 patients (3.3%) underwent redo-operations. The patients were divided into four groups according to the type of surgery: all patients pooled together (2190), coronary artery surgery patients (1384, 63.2%, group I), valve surgery patients (706, 32.2%, group II) and combined (coronary plus valve) surgery patients (100, 4.6%, group III). Stepwise logistic regression analysis, performed to assess the risk factors for revisions due to bleeding showed aprotinin treatment to be the sole protective factor in all patients, group I and group II. In group III only the use of a hollow fiber membrane oxygenator proved a protective factor. Risk factors for revisions for bleeding were found to be aortic cross-clamp time in all patients, group I and group II. Use of the internal thoracic artery (ITA) was significant in group I pa...Continue Reading

Citations

Feb 5, 2004·The Annals of Thoracic Surgery·David M MoskowitzM Arisan Ergin
Mar 12, 1999·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·A ParolariP Biglioli
Apr 12, 2001·Journal of Intellectual Disability Research : JIDR·J McCarthy, J Boyd
Jan 17, 2008·Journal of Intellectual Disability Research : JIDR·D MantryA Jackson
May 1, 1998·The Annals of Thoracic Surgery·D Royston
Dec 1, 1996·The Annals of Thoracic Surgery·S Bélisle, J F Hardy
Jan 1, 1997·The Annals of Thoracic Surgery·D M al KhudhairiM el Sharkawy
Oct 5, 2010·The Journal of Thoracic and Cardiovascular Surgery·Thorsten DrewsRoland Hetzer
Apr 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·Dusko NezićPredrag Milojević
Dec 17, 2009·The Journal of Thoracic and Cardiovascular Surgery·Damien J LaParGorav Ailawadi
Jul 2, 1999·Anesthesia and Analgesia·A ParolariE Tremoli

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