The effect of high-flow nasal oxygen on hospital length of stay in cardiac surgical patients at high risk for respiratory complications: a randomised controlled trial

Anaesthesia
V ZochiosA A Klein

Abstract

There has been increased interest in the prophylactic and therapeutic use of high-flow nasal oxygen in patients with, or at risk of, non-hypercapnic respiratory failure. There are no randomised trials examining the efficacy of high-flow nasal oxygen in high-risk cardiac surgical patients. We sought to determine whether routine administration of high-flow nasal oxygen, compared with standard oxygen therapy, leads to reduced hospital length of stay after cardiac surgery in patients with pre-existing respiratory disease at high risk for postoperative pulmonary complications. Adult patients with pre-existing respiratory disease undergoing elective cardiac surgery were randomly allocated to receive high-flow nasal oxygen (n = 51) or standard oxygen therapy (n = 49). The primary outcome was hospital length of stay and all analyses were carried out on an intention-to-treat basis. Median (IQR [range]) hospital length of stay was 7 (6-9 [4-30]) days in the high-flow nasal oxygen group and 9 (7-16 [4-120]) days in the standard oxygen group (p=0.012). Geometric mean hospital length of stay was 29% lower in the high-flow nasal group (95%CI 11-44%, p = 0.004). High-flow nasal oxygen was also associated with fewer intensive care unit re-admi...Continue Reading

References

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Citations

Feb 16, 2019·Anaesthesia·A B Lumb, C R Thomas
Jun 5, 2019·Korean journal of anesthesiology·Hyun Joo Kim, Takashi Asai
Nov 26, 2020·Critical Care Explorations·Thomas S MetkusDavid A Morrow
May 31, 2017·The Cochrane Database of Systematic Reviews·Amanda CorleyAndrew F Smith
Mar 5, 2021·The Cochrane Database of Systematic Reviews·Sharon R LewisAndrew F Smith

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