PMID: 38270Sep 1, 1979

The effect of histamine-1 and histamine-2 antagonists on airway responses to histamine in the rhesus monkey

The Journal of Allergy and Clinical Immunology
P GreenbergerR Patterson

Abstract

This study used rhesus monkeys with consistent respiratory responses to aerosolized histamine. Two systems of histamine challenge were evolved to study the effects of histamine antagonists on the histamine-induced respiratory response. One system consisted of administering increasing subreactive concentrations of histamine until an airway response (H) occurred. This threshold histamine dose was repeated (H'). The pulmonary function changes occurring with the H' challenge were less intense than those with H. M, a histamine-2 receptor antagonist, when given before the H' dose was associated with a potentiated H' response compared with the threshold H response. This provides evidence for histamine-2 receptor sites in rhesus monkey airways. A second system used duplicate histamine challenges with a known reactive dose of histamine. In this system, the pulmonary function changes occurring with the repeated challenge (H') were greater than with the first reactive challenge dose (H). This H' response was inhibited partially with diphenhydramine, a histamine-1 receptor antagonist. These two systems of histamine challenge provide an experimental model for evaluating pharmacologic alteration of histamine-induced respiratory responses. Th...Continue Reading

References

Jan 1, 1979·Neuroscience·J Bligh
May 1, 1981·Journal of Pharmacological Methods·R M O'NeilF R Goodman
Jul 9, 2004·Respiratory Physiology & Neurobiology·Nathalie SchützWalid Habre
Aug 1, 1982·Chest·E N SchachterB Gerstenhaber
Jan 31, 2002·Anesthesiology·Walid HabreFerenc Peták

Citations

Apr 21, 1977·The New England Journal of Medicine·A A MathéC A Leslie
Jun 1, 1977·The Journal of Clinical Investigation·W W Busse, J Sosman
Apr 1, 1978·The Journal of Allergy and Clinical Immunology·R Patterson, K E Harris
Jul 1, 1977·European Journal of Pharmacology·R D Krell, L W Chakrin
Jul 27, 1973·Nature·L M Lichtenstein, E Gillespie
Apr 21, 1972·Nature·J W BlackE M Parsons
Nov 1, 1946·The Journal of Clinical Investigation·J J Curry

Related Concepts

Histamine Measurement
Histamine-1 Receptor Antagonist [EPC]
HRH2 protein, human
Diphenhydramine
Metiamide Monohydrochloride
Peak Expiratory Flow Rate Measurement
Histamine Receptor Antagonists [MoA]
Antihistamines, Classical
Histamine Challenge
Dimedrol

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.