PMID: 6109747Jan 1, 1981Paper

The effect of histamine on epidermal outgrowth: its possible dual role as an inhibitor and stimulator

The Journal of Investigative Dermatology
T AoyagiC W Woodyard

Abstract

We have investigated the effect of histamine on pig epidermal cell outgrowths in vitro. Histamine inhibited the epidermal cell outgrowths (and also mitosis). This inhibition was partially counteracted by a specific H2 antagonist, cimetidine. Inhibition was maximal at a histamine concentration of 10(-4) M and was less at 10(-3) M. These histamine concentrations respectively coincide with the optimal concentrations for accumulating intracellular cyclic AMP (via H2 receptors) and cyclic GMP (via H1 receptors) in the same pig epidermal slice system. 4-Methyl-histamine, a pure H2 agonist, which only increased the intracellular cyclic AMP level but not the cyclic GMP level, caused a maximal outgrowth inhibition at 10(-3) M. Attempts to counteract the histamine effects due to cyclic GMP accumulation by various H1 antagonists (so that 10(-3) M histamine would have caused maximal outgrowth inhibition) were unsuccessful, since the addition of each H1 antagonist alone strongly inhibited the outgrowth. These data strongly suggest a dual role of histamine through the cyclic nucleotide system; i.e., histamine inhibits epidermal cell growth by elevating the intracellular cyclic AMP level via an H2 receptor, while histamine at high concentrati...Continue Reading

References

Jun 23, 1976·Biochimica Et Biophysica Acta·K Iizuka HadachiV Levine
Oct 1, 1976·Physiological Reviews·D L Friedman
Oct 22, 1976·Biochimica Et Biophysica Acta·H IizukaV Levine
Nov 1, 1979·The Journal of Investigative Dermatology·H IizukaV Levine
Feb 1, 1979·The Journal of Investigative Dermatology·K M HalprinN E Fusenig
Jul 1, 1975·The British Journal of Dermatology·K YoshikawaV Levine
Jul 1, 1972·The Journal of Investigative Dermatology·J J VoorheesE R Harrell
Oct 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J W HaddenN D Goldberg
Sep 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·R A HarperD P Chopra

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Citations

Jan 1, 1990·Immunopharmacology and Immunotoxicology·A R RezaiV Kermani-Arab
Nov 1, 1982·The British Journal of Dermatology·K AdachiV Levine
Sep 1, 1981·The British Journal of Dermatology·T AoyagiY Miura
Jun 1, 1988·International Journal of Dermatology·J Fransson, H Hammar
Apr 1, 1989·Agents and Actions·W A FogelC Maslinski
Nov 1, 1982·The British Journal of Dermatology·M W Greaves, M G Davies
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·D J Donaldson, J T Mahan
Apr 1, 1983·The Journal of Investigative Dermatology·O NemotoV Levine
Nov 1, 1986·Pharmacological Research Communications·A BerndH Holzmann

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