PMID: 8950301Jan 1, 1996Paper

The effect of histamine type 2 receptor antagonists on human immunodeficiency virus (HIV) replication: identification of a new class of antiviral agents

Life Sciences
A S Bourinbaiar, E C Fruhstorfer

Abstract

The suppression of human immunodeficiency virus (HIV) replication by histamine type 2 (H2) receptor antagonists, cimetidine, ranitidine, and famotidine was examined in vitro. The 50% reduction (IC50) in p24 antigen expression caused by the anti-ulcer agent, cimetidine, was observed at 26.8 nM with IC100 at 10 microM. Unlike azidothymidine-a reverse transcriptase inhibitor-cimetidine blocked HIV infection without affecting cell growth, as no cytotoxicity was observed even at the highest 1 mM dose. Ranitidine and famotidine were less potent than cimetidine. H1 antagonists, cyproheptadine and diphenhydramine, had no effect on HIV replication. Although the activity of cimetidine was observed at concentrations attainable by oral administration, the mechanism of anti-HIV action is unknown. This is the first report on antiretroviral action of H2 blockers. Further studies are warranted to establish the potential of a new class of anti-HIV agents with immunomodulating properties.

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Citations

Aug 5, 2010·The Veterinary Clinics of North America. Exotic Animal Practice·Jerry MurrayRoger K Maes
Jan 5, 2011·Research in Veterinary Science·Ha-Hyun KimWoo Song Lee
Sep 30, 2016·Frontiers in Pharmacology·Yuanyuan SunGuang Du
Sep 15, 2000·Pediatrics International : Official Journal of the Japan Pediatric Society·Y GuH Ushijima
Jun 25, 2020·Journal of Biomolecular Structure & Dynamics·Parth Sarthi Sen GuptaMalay Kumar Rana
Aug 28, 2020·The American Journal of Gastroenterology·Jeffrey F MatherRaymond G McKay
May 7, 2020·JMIR Public Health and Surveillance·Moshe RogosnitzkyAlejandro R Jadad
Jul 1, 2020·Digestive Diseases and Sciences·Enrik John T Aguila, Ian Homer Y Cua
Dec 16, 2020·Journal of Intensive Care Medicine·Pierre KoryPaul E Marik
Jan 4, 2021·Pharmacological Reports : PR·Anurag Singh, Vandana Gupta
Jan 26, 2021·Journal of Biomolecular Structure & Dynamics·Ahmed A IsholaSubhash Chandra
Nov 19, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Madeleine Ennis, Katerina Tiligada
Mar 24, 2021·Drug Research·Santenna ChenchulaBalakrishnan Sadasivam
Feb 10, 2021·The American Journal of Gastroenterology·Azza ShoaibiPatrick Ryan
May 14, 2021·The American Journal of Gastroenterology·Azza ShoaibiPatrick Ryan
Oct 20, 2020·ACS Pharmacology & Translational Science·Parth Sarthi Sen Gupta, Malay Kumar Rana

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