The effect of hormone replacement therapy on vitamin E status in postmenopausal women

Maturitas
Y WenJ Feely

Abstract

Vitamin E (alpha-tocopherol) is the most important dietary antioxidant found in lipids and cell membranes and its intake is inversely related to the incidence of atherosclerotic cardiovascular disease. Oestrogen-containing oral contraceptives may decrease plasma vitamin E level in young women. We investigated if oestrogen-containing hormone replacement therapy (HRT) may have the same effect on vitamin E status in postmenopausal women Eighteen healthy postmenopausal women took a combination of oestrogen/progestogen (Harmogen Provera) therapy and another ten acted as a control group. Blood samples were taken at baseline and repeated after 3 and 6 months in both groups. Vitamin E in plasma, red cells and isolated low-density lipoprotein (LDL) was measured as alpha-tocopherol by high-performance liquid chromatography. Vitamin E status showed no change in either group after 3 and 6 months in comparison to its baseline value. Combined oestrogen/progestogen HRT for 6 months in healthy postmenopausal women did not alter vitamin E. status in vivo.

References

Jun 15, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·C SierraM de Ramón
Jan 1, 1991·The American Journal of Clinical Nutrition·H EsterbauerG Waeg
Sep 14, 1990·Biochimica Et Biophysica Acta·K MukaiM Nakano
May 1, 1987·The American Journal of Clinical Nutrition·K F GeyH B Stähelin
Jan 1, 1986·Methods in Enzymology·B H ChungJ T Cone
Jun 21, 1995·JAMA : the Journal of the American Medical Association·H N HodisS P Azen
Sep 17, 1994·Lancet·J L Witztum
Dec 1, 1994·American Heart Journal·J E Manson
May 20, 1993·The New England Journal of Medicine·M J StampferW C Willett
May 20, 1993·The New England Journal of Medicine·E B RimmW C Willett
May 2, 1996·The New England Journal of Medicine·L H KushiR M Bostick

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Citations

Nov 6, 1998·Disease-a-month : DM·W B Cutler, E Genovese-Stone
Aug 5, 2011·Canadian Journal of Physiology and Pharmacology·Amr M Abbas, Ayman Z Elsamanoudy
May 20, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mustafa NaziroğluRemzi Atilgan

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