The effect of human cumulus cells on the maturation and developmental potential of immature oocytes in ICSI cycles.

Journal of Assisted Reproduction and Genetics
Aijun ZhangChen Xu

Abstract

To investigate the effect of human cumulus cells on the maturation and developmental potential of immature oocytes in ICSI cycles. Immature oocytes were randomly divided into two groups: the cumulus-denuded oocyte group (group A) and the cumulus-intact oocyte group (group B). Only oocytes that reached metaphase II (MII) stage after in vitro maturation were used in the ICSI procedure. In vivo mature sibling MII oocytes served as the control group. Maturation rate, fertilization rate, embryo quality and developmental potential were examined. There was no significant difference in maturation rate between group A (68.16%) and group B (70.49%; P > 0.05). The total fertilization rate among the three groups was comparable (P > 0.05), while the zygotes with two pronuclei in group A (74.59%) or group B (75.97%) were significantly lower than those in control group (84.29%; P < 0.05). The available embryo rate in group A (11.49%) was markedly lower than that in group B (27.66%; P < 0.05), and both of them were significantly lower than that in control group (62.38%; P < 0.05). The proportion of ≥6-cell embryos in group B (45.74%) was notably higher than in group A (26.44%; P < 0.05), and both were markedly lower than in control group (65.9...Continue Reading

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Citations

Jul 17, 2018·Endocrinology·Rebecca L RobkerDarryl L Russell
Jan 30, 2021·Human Fertility : Journal of the British Fertility Society·Huiying JieDavid Yiu Leung Chan
Jun 26, 2021·Journal of Assisted Reproduction and Genetics·Rachel S MandelbaumAli Ahmady

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