PMID: 3767273Jul 1, 1986Paper

The effect of hydropenia and oral water loading on renal lysozyme handling and N-acetyl-beta-D-glucosaminidase excretion in man

Annals of Clinical Biochemistry
M T Houser

Abstract

To substantiate the effects of urine flow rate on renal lysozyme handling and N-acetyl-beta-D-glucosaminidase (NAG) excretion, experiments were performed in normal human subjects. Urine flow rate was varied by overnight fluid deprivation and progressive diuresis induced by oral water loading. Lysozyme measurements were made using an improved turbidimetric method and NAG determinations using a modified fluorometric assay utilising individual recovery techniques. Fractional lysozyme clearance and lysozyme excretion demonstrated a nearly linear relationship with urine flow rate (r = 0.78, r = 0.80, P less than 0.0005), and both were elevated significantly in samples obtained during diuresis. NAG excretion, however, demonstrated a significant but weak correlation (r = 0.47, P less than 0.005) with fractional urine flow rate. A significant (P less than 0.05) difference in NAG activity occurred only during the period of hydropenia, when a decrease in excretion was observed. These findings suggest that the effect of diuresis on lysozyme excretion should be considered in studies utilising this enzyme as a marker of renal injury.

References

Jul 7, 1979·British Medical Journal·G GuarnieriS Lin
Nov 18, 1978·British Medical Journal·S Harding, A J Munro
Jul 23, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·S M TuckerR G Price
Aug 16, 1975·British Medical Journal·J M WellwoodN F Jones
Feb 1, 1973·Pediatric Research·C ChaimovitzA Benderli
Sep 1, 1970·Clinical Science·T M Barratt, R Crawford
Jun 1, 1984·The American Journal of Medicine·B R MeyerM M Reidenberg

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

© 2021 Meta ULC. All rights reserved