The effect of hydroxyapatite nanoparticles on adipogenic differentiation of human mesenchymal stem cells

Journal of Biomedical Materials Research. Part a
Xing YangQingling Feng

Abstract

Due to its excellent biocompatibility, nanosized hydroxyapatite (nHA) has drawn much attention for various applications in biomedical fields. There are growing concerns about its biosecurity; however, little is known about its effects on adipogenesis. In the present study, nHA with three different sizes were synthesized, and the in vitro effects of nHA on cell proliferation and adipogenic differentiation of human mesenchymal stem cells (hMSCs) were investigated. The results clearly show that nHA does not affect the cell viability, the lipids droplets formation, triglyceride (TG) synthesis, and the expression of adipogenic marker genes/proteins of hMSCs at concentrations lower than 50 μg/mL. It is concluded that the adipogenic differentiation potential of hMSCs is not affected by nHA at noncytotoxic concentrations. These will provide a reference for the applications of nHA in biomedical fields. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1822-1831, 2018.

References

Nov 10, 1995·The Journal of Biological Chemistry·P E SchererH F Lodish
Sep 11, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S T DingH J Mersmann
Sep 11, 2002·Journal of Biomedical Materials Research·S Koutsopoulos
Apr 16, 2009·Nano Letters·D W Boukhvalov, M I Katsnelson
Feb 16, 2010·Dental Materials : Official Publication of the Academy of Dental Materials·Mehdi Sadat-ShojaiLeila Nasiri Khanlar
Sep 29, 2011·Nature Reviews. Molecular Cell Biology·Ana G Cristancho, Mitchell A Lazar
Apr 6, 2013·Tissue Engineering. Part B, Reviews·Siti Maisurah ZakariaJohn A Jansen
Apr 16, 2013·Acta Biomaterialia·Mehdi Sadat-ShojaiAhmad Jamshidi
May 15, 2013·Advanced Materials·Akhilesh K GaharwarAli Khademhosseini
May 9, 2014·Journal of Biomedical Nanotechnology·Xujie LiuQingling Feng
Dec 3, 2014·Journal of Colloid and Interface Science·Wan-Kyu KoIl Keun Kwon
Jun 12, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Wei ChenYa-Ping Guo
Jun 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhaoming LiuRuikang Tang
Feb 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Cancan ZhaoKaili Lin

❮ Previous
Next ❯

Citations

Oct 6, 2018·Journal of Biomedical Materials Research. Part a·Xing YangQingling Feng
Sep 19, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoshie AraiSoo-Hong Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.