The effect of hyoscine on dobutamine requirement in spontaneously breathing horses anaesthetized with halothane

Veterinary Anaesthesia and Analgesia
Kate E Borer, K W Clarke

Abstract

To determine whether hyoscine has a sparing effect on the volume of dobutamine required to maintain mean arterial pressure (MAP) at 70 mmHg in horses anaesthetized with halothane. Prospective, randomized, controlled clinical trial. Twenty adult horses weighing 507 +/- 97 kg (mean +/- SD), aged 10 +/- 5 years. Pre-anaesthetic medication in all horses was intramuscular (IM) acepromazine (40 mug kg(-1)) and intravenous (IV) detomidine (0.02 mg kg(-1)). Anaesthesia was induced with ketamine (2.2 mg kg(-1) IV) and diazepam (0.02 mg kg(-1) IV), and maintained with halothane in oxygen. Horses breathed spontaneously. Flunixin (1.1 mg kg(-1) IV) was given to provide analgesia. Heart rate, ECG, invasive arterial pressure, respiratory rate, percentage end-tidal carbon dioxide, percentage end-tidal halothane and partial pressure of oxygen and carbon dioxide in arterial blood and blood pH were monitored. Dobutamine was infused by an infusion pump to maintain MAP at 70 mmHg. Horses were randomly assigned to receive saline or hyoscine (0.1 mg kg(-1)) IV 30 minutes after induction. The heart rate, MAP and volume of dobutamine infused over 30-minute periods were measured and analysed statistically using a one-way anova. After administration of ...Continue Reading

References

Sep 1, 1990·Equine Veterinary Journal·G NymanG Hedenstierna
Jan 1, 1990·Veterinary Research Communications·F GasthuysD Parmentier
Sep 1, 1986·Equine Veterinary Journal·K W Clarke, P M Taylor
Aug 1, 1968·British Journal of Anaesthesia·L W HallW S Tyler
Nov 8, 1969·The Veterinary Record·K W Clarke, L W Hall
Feb 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·T R GeimerR D Gleed
May 15, 1998·The Veterinary Record·J A MarquesC A Valadão
Nov 27, 2001·Equine Veterinary Journal·S L Freeman, G C England
Apr 14, 2004·American Journal of Veterinary Research·Francisco J Teixeira NetoSumit Duronghphongtorn

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Citations

Mar 19, 2013·The Veterinary Clinics of North America. Equine Practice·Stijn Schauvliege, Frank Gasthuys
Mar 1, 2014·Veterinary Anaesthesia and Analgesia·João H PerottaCarlos A A Valadão

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