PMID: 16529171Mar 15, 2006Paper

The effect of hyperbaric air exposure on concentrations of malondialdehyde and some parameters of the antioxidant system in rat blood

Annales Academiae Medicae Stetinensis
Marzena Staniszewska

Abstract

Hyperbaric air exposure (ExH) produces potentially harmful effects in organisms due to increased oxygen pressure and creates the risk of gas emboli during decompression. The effect of hyperbaric air exposure on free radical generation can be studied by varying the dynamics of tissue desaturation and total time of exposure to hyperbaric oxygen. The aim of the present study in rats was to (1) assess the effect of hyperbaric air exposures with accelerated decompression on free radical generation by measuring serum concentrations of malondialdehyde produced during beta-elimination of polyunsaturated fatty and by determining the serum antioxidant status; and (2) examine the effect of hyperbaric air exposures on activities of the main antioxidant enzymes. The study was performed in 50 male Wistar rats dividet into one control (n=10) and two study groups (II and III, n=20 each). The study groups were divided into two equal subgroups (IIa, IIb, IIIa, IIIb) and exposed to hyperbaric air under maximal pressure of 6 ata, with a single session in group II and three session 60 minutes apart in group III. Subgroups IIa and IIIa underwent stepwise decompression during 101 minutes, while subgroups IIb and IIIb during 67 minutes. Serum concentr...Continue Reading

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