The effect of hyperbaric oxygen therapy on blood vessel function in diabetes mellitus

Medical Hypotheses
Sanela UnfirerInes Drenjancevic-Peric

Abstract

Prolonged untreated diabetes mellitus leads to microangiopathy, tissue hypoxia and ischemic lesions; it increases the risk for stroke and exacerbates brain tissue damage following ischemia. Patients exhibit advanced atherosclerosis in coronary and cerebral arteries as well as enhanced vascular responsiveness to vasoconstrictors, an attenuated response to vasodilators and impaired autoregulation of cerebral blood flow. Altered endothelial function of arterioles and an impaired vasomotor function of resistance vessels could contribute to altered regulation of regional blood flow and insufficient tissue perfusion in diabetes mellitus. Hyperbaric oxygen therapy is shown to contribute to the healing of ischemic ulcerations in diabetic patients and to improvement of several other pathologic conditions. However, information about the mechanism of how this therapy works is still very limited. We postulate that hyperbaric oxygen therapy has an effect on vascular function by modulating mechanisms of vascular responses to various dilator and constrictor agonists in cerebral resistance vessels, leading to restored vascular reactivity. In accordance to this, the therapy affects production of vasodilators and vasoconstrictors, as well as the...Continue Reading

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Citations

Aug 15, 2013·Current Opinion in Lipidology·Elke MarschMat J A P Daemen
Nov 28, 2013·Journal of Vascular Research·Ines Drenjancevic, Aleksandar Kibel
May 21, 2013·Diabetes Research and Clinical Practice·Vladimira VuleticVida Demarin

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