The effect of hyperinsulinaemic-euglycaemic clamp and exercise on bone remodeling markers in obese men

BoneKEy Reports
Itamar LevingerEgo Seeman

Abstract

Bone remodelling markers (BRMs) are suppressed following a glucose load and during glucose infusion. As exercise increases indices of bone health and improves glucose handling, we hypothesised that, at rest, hyperinsulinaemic-euglycaemic clamp will suppress BRMs in obese men and that exercise prior to the clamp will prevent this suppression. Eleven obese nondiabetic men (age 58.1±2.2 years, body mass index=33.1±1.4 kg m(-2) mean±s.e.m.) had a hyperinsulinaemic-euglycaemic clamp (HEC) at rest (Control) and 60 min post exercise (four bouts × 4 min cycling at 95% of hazard ratiopeak). Blood samples were analysed for serum insulin, glucose, bone formation markers, total osteocalcin (tOC) and procollagen type 1 N-terminal propeptide (P1NP), and the bone resorption marker, β-isomerised C-terminal telopeptides (β-CTx). In the control trial (no exercise), tOC, P1NP and β-CTx decreased with HEC by >10% compared with baseline (P<0.05). Fasting serum glucose, but not insulin, tended to correlate negatively with the BRMs (β range -0.57 to -0.66, p range 0.051-0.087). β-CTx, but not OC or P1NP, increased within 60 min post exercise (∼16%, P<0.01). During the post-exercise HEC, the glucose infusion rate was ∼30% higher compared with the no e...Continue Reading

References

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May 28, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Itamar LevingerEgo Seeman
Dec 4, 2014·Clinical Medicine : Journal of the Royal College of Physicians of London·Alistair Lumb

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Citations

Feb 26, 2016·BoneKEy Reports·Tara C Brennan-Speranza, Itamar Levinger
Jan 16, 2018·Acta Diabetologica·Caterina ConteNicola Napoli
Aug 24, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lewan ParkerItamar Levinger
May 10, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Hassane ZouhalGeorges Jabbour
Jul 31, 2018·Frontiers in Endocrinology·Jakob Starup-LindeSøren Gregersen
Oct 12, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L ParkerI Levinger

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