PMID: 8972388Dec 1, 1996Paper

The effect of hyperosmolality on the rate of heat production of quiescent trabeculae isolated from the rat heart

The Journal of General Physiology
D LoiselleG Elzinga

Abstract

We have measured the rate of heat production of isolated, quiescent, right ventricular trabeculae of the rat under isosmotic and hyperosmotic conditions, using a microcalorimetric technique. In parallel experiments, we measured force production and intracellular calcium concentration ([Ca2+]i). The rate of resting heat production under isosmotic conditions (mean +/- SEM, n = 32) was 100 +/- 7 mW (g dry wt)-1; it increased sigmoidally with osmolality, reaching a peak that was about four times the isosmotic value at about twice normal osmotic pressure. The hyperosmotic thermal response was: (a) abolished by anoxia, (b) attenuated by procaine, (c) insensitive to verapamil, ouabain, and external calcium concentration, and (d) absent in chemically skinned trabeculae bathed in low-Ca2+ "relaxing solution." Active force production was inhibited at all osmolalities above isosmotic. Passive (tonic) force increased to, at most, 15% of the peak active force developed under isosmotic conditions while [Ca2+]i increased, at most, 30% above its isosmotic value. We infer that hyperosmotic stimulation of resting cardiac heat production reflects, in large part, greatly increased activity of the sarcoplasmic reticular Ca2+ ATPase in the face of i...Continue Reading

Citations

May 3, 2005·Pflügers Archiv : European journal of physiology·C Widén, C J Barclay
Aug 8, 2007·Pflügers Archiv : European journal of physiology·Rafael A RicardoJosé W M Bassani
Jan 25, 2003·Clinical and Experimental Pharmacology & Physiology·S-J GuildD S Loiselle
Feb 27, 2003·Clinical and Experimental Pharmacology & Physiology·J R D CropperD S Loiselle
Sep 16, 2009·The Journal of General Physiology·Soyeon GooDenis Loiselle
Apr 26, 2005·Experimental Physiology·Chikako Nakajima-TakenakaMiyako Takaki
Jul 17, 2019·Apoptosis : an International Journal on Programmed Cell Death·Juan Ignacio BurgosMartin Vila Petroff
Aug 24, 2010·American Journal of Physiology. Heart and Circulatory Physiology·June-Chiew HanDenis S Loiselle
Jan 11, 2011·American Journal of Physiology. Heart and Circulatory Physiology·June-Chiew HanDenis S Loiselle
May 24, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Callum M JohnstonAndrew J Taberner
Mar 27, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Callum M JohnstonAndrew J Taberner
Nov 22, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Denis S LoiselleAndrew James Taberner
Dec 24, 2017·Basic Research in Cardiology·Malena MorellMartin Vila Petroff
May 30, 2002·Analytical Chemistry·Erik A JohannessenJonathan M Cooper

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.