PMID: 3763379Sep 1, 1986Paper

The effect of hypokinesia and hypodynamia on protein turnover and the growth of four skeletal muscles of the rat

Pflügers Archiv : European journal of physiology
D F GoldspinkG Goldspink

Abstract

An animal suspension model has been used to simulate the weightlessness experienced during space travel. This procedure results in a reduction in the normal shortening (i.e. hypokinesia) and force generation functions of hind limb muscles (i.e. hypodynamia). The ensuing muscle atrophy was studied over 12 days in different muscle types. Slow muscles (e.g. the soleus) underwent a more pronounced atrophy than intermediate (i.e. gastrocnemius) and fast phasic muscles (e.g. extensor digitorum longus). In all muscle types inactivity resulted in a smaller accumulation of DNA and losses of RNA and protein after 5 days. The latter arose from a decrease in the rate of protein synthesis (measured in vivo) and an increase in protein breakdown. Increased specific activities of cathepsins B and D also supported the view that there is an increased proteolysis after hypokinesia and hypodynamia. When the inactive soleus was simultaneously held in a lengthened (stretched) state the atrophy was prevented through a large increase in the fractional rate of protein synthesis. Protein degradation remained elevated with stretch, thereby slowing the growth of these muscles relative to those in pair-fed, ambulatory controls. The much smaller atrophy of ...Continue Reading

References

Sep 22, 1978·Science·E R Morey, D J Baylink
Apr 1, 1977·Clinical Science and Molecular Medicine·A J SargeantA Young
Jan 1, 1975·The American Journal of Physiology·A L Goldberg, D F Goldspink
Jul 1, 1986·Journal of Applied Physiology·P LoughnaD F Goldspink
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D F GoldspinkF J Kelly
Jan 1, 1973·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M A ArianoV R Edgerton
Jul 1, 1984·The American Journal of Physiology·P A WatsonF W Booth
Jan 1, 1980·The American Journal of Physiology·R G HollyP A Molé
Mar 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·X J MusacchiaT P Davis

❮ Previous
Next ❯

Citations

Jan 1, 1991·Cell and Tissue Research·D J Dix, B R Eisenberg
Sep 28, 2005·European Journal of Applied Physiology·Kristina CsuklyPhillip Gardiner
May 3, 2011·European Journal of Applied Physiology·K J Hackney, L L Ploutz-Snyder
Jan 15, 2008·Pflügers Archiv : European journal of physiology·François B FavierDamien Freyssenet
Aug 1, 1994·Metabolism: Clinical and Experimental·K A MunozE J Henriksen
Jan 1, 1990·Comparative Biochemistry and Physiology. A, Comparative Physiology·M LacailleC Simard
Apr 1, 1995·Comparative Biochemistry and Physiology. Part A, Physiology·R NagaokaN Akaike
Feb 26, 2004·Acta Astronautica·Chrysoula Kourtidou-PapadeliOlympia Guiba-Tziampiri
May 19, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Stuart M Phillips
Apr 13, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Elisa I GloverStuart M Phillips
Aug 17, 2011·Journal of Nutrition and Metabolism·Jennifer A BunnDarryn S Willoughby
Apr 13, 2012·Journal of Biomedicine & Biotechnology·E V Kachaeva, B S Shenkman
Jan 24, 2004·American Journal of Respiratory and Critical Care Medicine·Theodoros Vassilakopoulos, Basil J Petrof
Apr 12, 2007·BMC Musculoskeletal Disorders·John EashKevin Hannon
Sep 29, 2001·Journal of Physiological Anthropology and Applied Human Science·N YoshidaM Fukunaga
Dec 21, 2002·Journal of Physiological Anthropology and Applied Human Science·Madoka IkemotoTakeshi Nikawa
May 25, 2010·Journal of Nutritional Science and Vitaminology·Masahiro KanazawaToshiyasu Suzuki
Jul 6, 2010·European Journal of Applied Physiology·T van WesselR T Jaspers
Aug 11, 2006·Canadian Journal of Physiology and Pharmacology·Deborah L Enns, Angelo N Belcastro
Nov 4, 2008·Micron : the International Research and Review Journal for Microscopy·Mamie Mizusaki IyomasaIi-Sei Watanabe
Nov 19, 2005·Scandinavian Journal of Medicine & Science in Sports·P A Huijing, R T Jaspers
Feb 16, 2012·Muscle & Nerve·Jonathan M Van DykeDanny A Riley
Jun 30, 2009·Scandinavian Journal of Medicine & Science in Sports·M J RennieS M Philips
Dec 15, 2004·Experimental and Molecular Pathology·Marek KujawaEwa Jankowska-Steifer
Nov 1, 1994·Metabolism: Clinical and Experimental·M E Tischler
Oct 7, 2004·Experimental Physiology·Christy M PicconeKathleen M McCormick
Jun 19, 2013·The International Journal of Biochemistry & Cell Biology·Anthony M J SanchezHenri Bernardi
Jan 22, 2014·European Journal of Sport Science·Frédéric DerbréJosé Viña
Feb 20, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·T D LohuisT D I Beck
Jan 5, 2005·The Journal of Nutritional Biochemistry·T Peter SteinCharles E Wade
Nov 22, 2016·Bioscience, Biotechnology, and Biochemistry·Jing WangXiaoping Chen
Mar 2, 2012·Acta Cirúrgica Brasileira·André de Sá Braga OliveiraPaloma Lys de Medeiros
Sep 10, 2004·American Journal of Physiology. Cell Physiology·Robert W Jackman, Susan C Kandarian
Mar 22, 2016·Endocrinology and Metabolism·Su Han ChoWook Song
Oct 27, 2004·American Journal of Physical Medicine & Rehabilitation·Takahiro SasaNatsuo Yasui
Jun 6, 2006·Journal of Muscle Research and Cell Motility·Hualin SunXiaosong Gu
Oct 23, 2008·Clinical Orthopaedics and Related Research·Silvia SchmutzBruno Fuchs
Sep 4, 2009·Medicine and Science in Sports and Exercise·Maria L Urso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.