The effect of hypophysectomy on somatostatin-like immunoreactivity in discrete hypothalamic and extrahypothalamic nuclei

Endocrinology
L C Terry, W R Crowley

Abstract

Several hypothalamic and extrahypothalamic sites that have high concentrations of somatostatin-positive nerve terminals and/or cell bodies are important in the regulation of GH secretion. GH is capable of inhibiting its own secretion under certain prescribed conditions, and a short loop feedback regulatory mechanism may involve somatostatinergic pathways. The purpose of this investigation was to determine the effect of removal of GH by hypophysectomy on the content of somatostatin-like immunoreactivity (SLI) in discrete hypothalamic and extrahypothalamic nuclei. Individual nuclei were removed from frozen brain sections of hypophysectomized and sham-operated male rats. The tissue content of somatostatin was determined by a specific RIA. The content of SLI in the median eminence of hypophysectomized animals was significantly reduced by 38%, compared to sham-operated controls (278 +/- 53.2 vs. 447.0 +/- 57.4 pg/microgram protein, respectively). Significant reductions of SLI in the medial preoptic (50%), arcuate (33%), and periventricular (30%) nuclei were also observed in hypophysectomized animals when compared to controls (10.2 +/- 1.6 vs. 20.0 +/- 3.0; 60.2 +/- 8.2 vs. 89.8 +/- 13.3; and 19.4 +/- 1.8 vs. 27.8 +/- 3.1 pg/microgra...Continue Reading

Citations

Dec 1, 1987·Cellular and Molecular Neurobiology·W S Young, R T Zoeller
Dec 1, 1983·Brain Research Bulletin·K T BorerA I Vinik
Feb 1, 1981·The Journal of Clinical Investigation·H Sacks, L C Terry
Feb 1, 1983·British Journal of Pharmacology·K Jhamandas, M Sutak

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