PMID: 1180068May 1, 1975Paper

The effect of imidazole and some of its derivatives on the guinea pig isolated auricles and frog nerve-muscle junction.

Acta Physiologica Polonica
Z KorsakG Lebrecht

Abstract

Imidazole and its simple derivatives exerted an positive inotropic action on isolated guinea pig heart auricles. The order activity was 2-Etlm greater than greater than 2-MeIm greater than N-MeIm greater than Im. The action of Im on heart auricles was partially blocked by mepyramine, but not by burmamide. Im and 2-MeIm increased EPP's amplitude and produced a generation of full spike potentials in fatigued nerve-muscle preparation. Both Im acts in absence of calcium from Ringer's solution. Possibility of the Im action as free calcium ions regulator is discussed.

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