PMID: 7090757Jun 1, 1982Paper

The effect of immobilization on collagen turnover in connective tissue: a biochemical-biomechanical correlation

Acta Orthopaedica Scandinavica
D AmielW H Akeson

Abstract

Immobilization of the knee joint for 9 weeks results in a reduction of the mechanical properties in the lateral collateral ligament. Specifically, ligament stiffness is reduced in this tissue. No statistical change in collagen mass was detected for the medial collateral ligament (MCL) or patellar tendon. An increase in collagen turnover (synthesis and degradation) was, however, found in the immobilized medial collateral ligament and patellar tendon. It is thus proposed that stiffness reduction is due to a change in the ligament substance itself, rather than a result of tissue atrophy.

Citations

Mar 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J A Buckwalter
Jun 22, 2005·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·A D GeorgoulisN Stergiou
Jul 9, 2011·Biomechanics and Modeling in Mechanobiology·Franco MaceriGiuseppe Vairo
Aug 21, 2013·Differentiation; Research in Biological Diversity·Yulia ShwartzElazar Zelzer
Dec 22, 1999·American Journal of Obstetrics and Gynecology·M P FitzgeraldL Brubaker
Mar 3, 1999·Journal of Biomechanics·A J RapoffR Vanderby
Jan 1, 1997·The Orthopedic Clinics of North America·F T BlevinsK G Vogel
Jan 16, 2003·Clinical Biomechanics·R WhiteD R Konn
Apr 1, 1994·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·P LaStayo, R Jaffe
Apr 1, 1996·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·K Schultz-Johnson
May 15, 2001·BJU International·M P FitzgeraldL Brubaker
May 27, 2011·Tissue Engineering. Part a·Colin Y L WoonJames Chang
Jul 9, 2009·Tissue Engineering. Part B, Reviews·Hugh A Benhardt, Elizabeth M Cosgriff-Hernandez
Mar 24, 2009·Exercise and Sport Sciences Reviews·Adamantios ArampatzisKirsten Albracht
May 1, 1990·Acta Physiologica Scandinavica·J KarpakkaT E Takala
Oct 16, 2010·Journal of Applied Physiology·Yu-Long SunPeter C Amadio
Aug 2, 2012·The Journal of Manual & Manipulative Therapy·Amy J BaylissMary T Loghmani
Jan 1, 1992·The Journal of Orthopaedic and Sports Physical Therapy·M R McCarthyJ L Yates-McCarthy
Dec 29, 2013·Biomechanics and Modeling in Mechanobiology·Yanxin LiuGuy M Genin
Oct 1, 1996·Acta Orthopaedica Scandinavica·M WiigL S Lohmander
May 16, 2009·Connective Tissue Research·Nicoletta GaglianoNicola Portinaro
Mar 27, 2002·Connective Tissue Research·M ShiibaM Yamauchi
Jan 1, 1992·Connective Tissue Research·J HarperE Harper
Jan 1, 1995·Connective Tissue Research·D O SillenceJ E Ault
May 17, 2008·Upsala Journal of Medical Sciences·Yoshihiro HagiwaraKouki Hatori
Dec 18, 2002·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·S ZaffagniniA Visani
Jun 1, 1991·Matrix : Collagen and Related Research·D AmielD Siegel
Feb 14, 2012·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·Roslyn B Evans
Jan 17, 2012·Journal of Shoulder and Elbow Surgery·Megan L KillianS Thomopoulos
Sep 20, 2011·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·James H-C WangBin Li
Aug 25, 2015·Journal of Biomechanics·Michele ConconiVincenzo Parenti-Castelli
Sep 25, 2010·Journal of Biomechanics·Adamantios ArampatzisKirsten Albracht
Dec 4, 2003·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Tokifumi MajimaKozaburo Hayashi
Aug 8, 2009·Journal of Voice : Official Journal of the Voice Foundation·Keiko Ishikawa, Susan Thibeault
Feb 1, 1988·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·E Ellis
Sep 11, 2007·Archives of Physical Medicine and Rehabilitation·Jian ZhouGuy Trudel
May 18, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S ThomopoulosL M Galatz
Aug 7, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Siva SundarGordon W Blunn
Dec 18, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·Rui LiangPamela A Moalli
Oct 11, 2005·Journal of Biomechanics·Michael F McDonaldBrian D Schmit
Feb 1, 1988·IEEE Transactions on Bio-medical Engineering·D Khalili, M Zomlefer
Feb 26, 2008·Archives of Physical Medicine and Rehabilitation·Patricia M Kluding, Marcio Santos
Jul 8, 2005·Journal of Biomechanics·James H-C Wang
Mar 25, 2005·Journal of Shoulder and Elbow Surgery·Mehmet DemirhanEmin Sunbuloglu
Aug 17, 2014·American Journal of Obstetrics and Gynecology·Rui LiangPamela A Moalli
Nov 5, 2013·American Journal of Obstetrics and Gynecology·Manon H KerkhofMarco N Helder
Jul 1, 1987·The Veterinary Clinics of North America. Small Animal Practice·J F Bardet
Jul 1, 1991·The Veterinary Clinics of North America. Small Animal Practice·G I Anderson
Mar 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S P ArnoczkyKeri Gardner
Oct 30, 2016·Physical Medicine and Rehabilitation Clinics of North America·Penny L Head
Nov 1, 1986·The American Journal of Sports Medicine·D AmielW H Akeson
Jan 1, 1994·The American Journal of Sports Medicine·L H LinderR C Haut
Oct 8, 1998·Foot & Ankle International·G A MurrellR F Warren
Sep 30, 1991·Biochemical and Biophysical Research Communications·M W OrthA C Vailas
May 1, 1987·The American Journal of Sports Medicine·S SandbergN Westlin
Jun 18, 2003·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·S BrünerG Germann
Nov 12, 2016·Orthopaedic Journal of Sports Medicine·Gev BhabraMing H Zheng
Mar 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kevin A HildebrandMei Zhang
May 2, 2018·The Journal of Orthopaedic and Sports Physical Therapy
Aug 4, 2018·The American Journal of Sports Medicine·Wei SuJinzhong Zhao
Feb 27, 2008·Clinical Orthopaedics and Related Research·Guy TrudelOdette Laneuville
Jan 17, 2007·Clinical Orthopaedics and Related Research·M UsubaS Miyakawa
Jan 1, 1987·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S L WooW H Akeson
Jul 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S O AbrahamssonL S Lohmander
May 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T MajimaK Kaneda
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G A MurrellT M Best
Jan 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M SonodaY Shimada
Jul 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T J MommersteegL Blankevoort
Jan 1, 1986·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D AmielW H Akeson
Nov 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J A HannafinP A Torzilli
Nov 1, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Eduardo L AbreuKathleen A Derwin
May 1, 1996·Journal of Biomechanical Engineering·N YamamotoK Kaneda
Oct 11, 2005·Muscle & Nerve·Constantinos N MaganarisArnold De Haan
Aug 2, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L M GalatzS Thomopoulos
Feb 8, 2006·Clinical Orthopaedics and Related Research·James H-C WangFreddie H Fu
Jun 1, 1987·Acta Orthopaedica Scandinavica·N P LarsenA W Parker
Oct 18, 2008·Journal of Applied Physiology·Britt ChristensenHenning Langberg
Oct 4, 2008·Journal of Applied Physiology·Helen L BirchA E Goodship
Jul 9, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kazuya IkomaToshikazu Kubo
Sep 1, 2017·Current Opinion in Otolaryngology & Head and Neck Surgery·Mami Kaneko, Shigeru Hirano
Oct 23, 2002·Journal of Applied Physiology·Paolo P ProvenzanoRay Vanderby
Oct 1, 1993·Acta Orthopaedica Scandinavica·D Lazovic, K Messner
Mar 16, 2002·Journal of Applied Physiology·K OhteraK-N An
Dec 1, 2018·BMC Musculoskeletal Disorders·Roine El-HabtaLudvig J Backman
Nov 1, 1996·Clinical Orthopaedics and Related Research·R B CampbellE Akelman
Jun 16, 2001·Journal of Applied Physiology·K KuboT Fukunaga
Jan 1, 1997·Cranio : the Journal of Craniomandibular Practice·H A Israel, S B Syrop
Aug 5, 2000·Foot & Ankle International·S G PneumaticosS G Trevino
Sep 19, 2015·Menopause : the Journal of the North American Menopause Society·Rui LiangPamela A Moalli
Jan 1, 1987·Acta Orthopaedica Scandinavica. Supplementum·C A Carlstedt
Apr 1, 1997·Scandinavian Journal of Medicine & Science in Sports·D T Kirkendall, W E Garrett
Apr 2, 2009·The Journal of Bone and Joint Surgery. British Volume·A P RumianA E Goodship
Aug 6, 2017·Scientific Reports·Alice BlumleinJennifer J McManus
Oct 14, 2017·Scientific Reports·Hanifeh KhayyeriHanna Isaksson
Aug 1, 1996·Scandinavian Journal of Medicine & Science in Sports·P ThuressonN Westlin
Nov 5, 1999·Clinical Orthopaedics and Related Research·J E CarpenterL J Soslowsky
May 1, 1991·The American Journal of Physiology·D A MartinezR E Grindeland
Jul 24, 2007·The Journal of Experimental Biology·Adamantios ArampatzisKirsten Albracht

Related Concepts

Kinematics
Zyderm
Connective Tissue
Hydroxyproline
Hypokinesia, Experimental
Knee Joint
Articular Ligaments
Patella
Proline
Tendons, Para-Articular

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