The effect of immune status, age and genetic background on induction of oral tolerance to Actinomyces viscosus in mice

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Wihaskoro SosrosenoPhil Bird

Abstract

The aim of the present study was to determine the effect of immune status, age and genetic background on the induction of oral tolerance to Actinomyces viscosus. Suppression of delayed type hypersensitivity (DTH) response and antigen-specific serum antibody levels could be induced in DBA/2 mice intragastrically and systemically immunized with A. viscocus, suggesting the induction of oral tolerance. In contrast, this immune suppression could be abrogated if the animals had been systemically immunized prior to the induction of oral tolerance with the same bacterium. Long-term systemic immunization prior to intragastric immunization with A. viscocus suppressed DTH response only. Cell transfer of this group of animals also suppressed DTH response in the donors, indicating the action of suppressor cells for inhibition of DTH response. Furthermore, oral tolerance to A. viscocus failed to occur in mice aged at 3 days and 1, 2, 4, 6 and 36 weeks old. Mice bearing H-2(d) haplotype were the most susceptible to oral tolerization, followed by H-2(b) and H-2(k). Therefore, the results of the presence study suggest that the induction of oral tolerance to A. viscosus in mice may be dependence on the immune status and genetic background but no...Continue Reading

References

Dec 1, 1990·Oral Microbiology and Immunology·G H BowdenS J Challacombe
May 1, 1989·Journal of Dental Research·R J Gibbons
Feb 1, 1982·The Journal of Experimental Medicine·H KiyonoS M Michalek
Aug 22, 2003·Oral Microbiology and Immunology·W SosrosenoG J Seymour
Apr 3, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Marina KorotkovaBirgitta Strandvik
Jan 25, 2005·Infection and Immunity·Manoj MuthukuruChristopher W Cutler
Feb 1, 2005·Annals of the New York Academy of Sciences·Andrew J Macpherson, Therese Uhr
Apr 22, 2006·Oral Microbiology and Immunology·W SosrosenoG J Seymour
Jun 24, 2006·Oral Diseases·W SosrosenoG J Seymour

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