The effect of immunosuppression on resistance to Rhodococcus equi in mice.

Veterinary Immunology and Immunopathology
P M BowlesM D Mutimer

Abstract

Rhodococcus equi, a natural pathogen of horses, produces lesions in mice following experimental infection. The effect of various immunosuppressing agents on the sequential development of these lesions has been assessed by measuring the growth of R. equi following intravenous or intranasal challenge and by histological examination. Cyclophosphamide treatment of mice, challenged intranasally, resulted in the development of lesions not unlike that seen in experimental and natural infection in foals. Cortisone acetate also impaired bacterial clearance from the lungs and affected the accumulation of mononuclear cells at infective foci. Most of the agents chosen to impair macrophage function failed to affect the resistance of mice to R. equi. Carbon, carrageenan and silica failed to alter significantly the growth kinetics of R. equi. Dextran sulphate depressed the rate of pulmonary clearance of organisms and affected the ability of animals to eliminate R. equi following rechallenge. Overall, these results support other evidence that cell mediated immunity is involved in host resistance to R. equi and that activated macrophages play a role in acquired immunity to this organism.

Citations

Jan 1, 1996·Trends in Microbiology·D M Mosser, M K Hondalus
Jun 16, 1997·Veterinary Microbiology·M K Hondalus
Mar 28, 2002·The Journal of Small Animal Practice·A Patel
May 21, 2009·FEMS Microbiology Reviews·Kristine von Bargen, Albert Haas
Feb 26, 2004·The Veterinary Record·F VerdonckE Cox

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