The effect of in vivo created vascularized neurotube on peripheric nerve regeneration

Injury
Abdul Kerim YapiciFatih Zor

Abstract

Creating vascularized nerve conduits for treatment of nerve gaps have been researched, however, these methods need microsurgical anastomosis thereby complicating the nerve repair process. Thus, the concept of vascularized nerve conduits has not popularized up till now. The aim of this study is to evaluate the effects of vascularized and non-vascularized biological conduits on peripheral nerve regeneration. Following ethical board approval, 15 Sprague-Dawley rats were used in the study. The rats were equally divided into three groups. In group I, a silicon rod was inserted next to the sciatic nerve of the rat and connective tissue generated around this rod was used as a vascularized biological conduit. In group II, a silicon rod was inserted into the dorsum of the rat and connective tissue generated around this rod was used as a non-vascularized biological conduit. In group III, autogenic nerve graft was used to repair the nerve gap. The contralateral sciatic nerve is used as a control in all rats. Macroscopic, electrophysiological and histomorphometric evaluations were performed to determine the nerve regeneration. There was no statistically significant difference between groups, in terms of latency. However, the mean amplitude...Continue Reading

Citations

Oct 20, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Papon MuangsanitJames B Phillips
Oct 16, 2019·Nanomedicine·Fatih ZorDavid F Williams
Jul 28, 2019·Journal of Tissue Engineering and Regenerative Medicine·Maliheh JahromiAbbas Bakhtiari
Jun 16, 2021·Trends in Endocrinology and Metabolism : TEM·Afonso MalheiroLorenzo Moroni

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