PMID: 8606423Mar 1, 1996Paper

The effect of indirect injury to peripheral nerves on wound healing after firearm wounds

The Journal of Trauma
X LaiL Chen

Abstract

This paper reports the pathologic and functional changes of the sciatic nerve indirectly injured by firearms and its effect on wound healing. Twelve dogs were used. Their hind legs were shot with 1.03-gram steel spheres, avoiding direct injury to the sciatic nerve. The experimental animals were divided into two groups according to the impact velocity, that is, a 1,500 m/sec high velocity projectile (HVP) group and a 400 m/sec, low velocity projectile (LVP) group as a control. After wounding, the same procedure was followed in all dogs. At intervals, the tissues of the wound track were excised to determine the level of cyclic nucleotides (cAMP, cGMP), secondary messengers of neurotransmitters, the activity of acetylcholinesterase (AChE), and the content of hydroxyproline, which indicates the degree of wound healing. The sciatic nerve next to the wound track was excised for light and electron microscopic study. The neurofilament in the sciatic nerve was examined by immunohistochemistry with monoclonal neurofilament-200 antibody. The results showed that the indirect injuries to the sciatic nerves of the HVP group were more severe than in those in the LVP group and included naked axons, stripped myelin sheaths, widened nodes of Ran...Continue Reading

Citations

Mar 17, 2004·The Journal of Urology·Richard A Santucci, Yao-Jen Chang
Oct 11, 2013·Journal of the Royal Army Medical Corps·John BreezeA E Hepper
May 12, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Andrea TóthIstván Sziklai
Jun 5, 2003·The Journal of Small Animal Practice·J M Levine, R B Fitch
Jul 1, 2020·ILAR Journal·Randall ReynoldsJohn Norton
Jul 22, 2015·Biomedical Instrumentation & Technology·Ilene Busch-Vishniac

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