PMID: 3533130Oct 1, 1986

The effect of inhaled 5-hydroxytryptamine (5-HT, serotonin) on airway calibre in man

British Journal of Clinical Pharmacology
M J CushleyS T Holgate

Abstract

Since platelet activation has been incriminated in the pathogenesis of asthma, we have investigated the effect of one of its major granule-derived mediators, 5-hydroxytryptamine (5-HT, serotonin) on airway calibre in normal (12), atopic non-asthmatic (12) and atopic asthmatic subjects (16). On separate days subjects inhaled increasing concentrations of 5-HT and methacholine, and airway response was measured as FEV1, Vmax30 and sGaw. All subjects bronchoconstricted with methacholine, geometric mean provocation concentrations causing a 20% fall in FEV1 (PCf20) for the normal, atopic non-asthmatic and atopic asthmatic subjects being 28.6, 18.3 and 0.71 mM respectively. In contrast, 5-HT up to a maximum concentration of 77 mM had no consistent effect on FEV1, Vmax30 or sGaw in any of the subject groups. Thus, in contrast to a variety of animals, 5-HT is unlikely to serve as a significant bronchoconstrictor mediator in man.

References

Jan 1, 1988·European Journal of Clinical Pharmacology·D J StottS G Ball
Jun 1, 1988·The Journal of Allergy and Clinical Immunology·K F ChungP J Barnes
Jul 4, 2009·Acta Pharmacologica Sinica·Jing-Wen LongYong-Xiao Cao
Jan 1, 1995·Allergy·M CazzolaF Rossi
Jun 5, 2014·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Lan WangYulin Ji
Jul 16, 2013·Experimental Lung Research·José Luis Arreola-RamírezPatricia Segura-Medina
Apr 1, 2008·Ageing Research Reviews·Craig S Atwood, Richard L Bowen
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jaime M CyphertBeverly H Koller
Dec 12, 2001·Cephalalgia : an International Journal of Headache·J BouJ M Palacios

Citations

Feb 1, 1985·Allergy·P Tønnesen
Nov 17, 1984·Lancet·J MorleyC P Page

Related Concepts

Pathogenic Aspects
Inhalation of Drugs
Pathogenesis
Dermatitis, Atopic
Serotonin Measurement
Airway Resistance
Serotonin
Bronchoconstrictor Agents
HTR7
Platelet Activation

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