PMID: 9176645May 1, 1997Paper

The effect of inhaled glucocorticosteroids in emphysema due to alpha1-antitrypsin deficiency

Respiratory Medicine
J T Wilcke, A Dirksen

Abstract

Despite the success of inhaled steroids in controlling asthma, the benefit in patients with chronic obstructive pulmonary disease (COPD) remains controversial. Five subjects with moderate to severe emphysema due to alpha 1-antitrypsin deficiency (phenotype PiZ) were followed with daily home spirometry in a 2 x 8 weeks, randomized double-blind, placebo-controlled, crossover study of inhaled budesonide 0.8 mg b.i.d. In three of the five patients, there was a statistically significant increase in the mean forced expiratory volume in 1 s (FEV1), and in two of these patients, there was also a statistically significant increase in the mean forced vital capacity (FVC) during budesonide treatment. A significant diurnal variation in FEV1 and FVC was found in three and two patients, respectively, but did not change significantly during treatment. These findings emphasize the need for renewed evaluation of inhaled steroids in the treatment of patients with emphysema, and indicate that individual patients may have significant clinical improvement.

References

Oct 1, 1979·British Journal of Diseases of the Chest·C K Connolly
Nov 1, 1994·Respiratory Medicine·A Bush, D Cramer
Oct 1, 1996·Thorax·A DirksenA Kok-Jensen

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Citations

Feb 27, 2001·Current Opinion in Pulmonary Medicine·R Pauwels
Oct 3, 2003·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
Mar 23, 2010·Respiratory Medicine·Emer KellyShane J O'Neill
Mar 17, 2007·Respiratory Medicine·Mario CazzolaNicola A Hanania
Jul 24, 2010·Therapeutic Advances in Respiratory Disease·Adriano R Tonelli, Mark L Brantly
Mar 6, 2008·Respiration; International Review of Thoracic Diseases·Luciano CordaClaudio Tantucci
Jan 27, 2004·The Journal of Pathology·R BlundellW A H Wallace
Dec 19, 2017·Respiration; International Review of Thoracic Diseases·Emma V LowAlice M Turner
Jul 13, 2012·The Cochrane Database of Systematic Reviews·Ian A YangKwun M Fong

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