PMID: 9426080Jan 13, 1998Paper

The effect of inhaling a dry powder of sodium chloride on the airways of asthmatic subjects

The European Respiratory Journal
S D AndersonA R Clark

Abstract

Wet aerosols of 4.5% sodium chloride (NaCl) are often used to assess the bronchial responsiveness associated with asthma. We questioned whether dry NaCl could be used as an alternative. Dry powder NaCl was inhaled from capsules containing either 5, 10, 20 or 40 mg to a cumulative dose of 635 mg. The powder was delivered via an Inhalator or Halermatic. The airway sensitivity to the dry and wet NaCl was compared in 24 patients with asthma aged 19-39 yrs. All subjects responded to both preparations and the geometric mean (95% confidence intervals) for the provocative dose of NaCl causing forced expiratory volume in one second (FEV1) to fall 20% from baseline (PD[20,NaCl]) for dry NaCl was 103 mg (68-157) versus 172 mg (102-292), p<0.03 for the wet NaCl. The response to dry NaCl was reproducible and on repeat challenge the PD20 was 108 mg (75-153). The mean maximum fall in FEV1 was approximately 25% on each of the two test days. Spontaneous recovery occurred within 60 min after challenge with dry NaCl and within 5 min after bronchodilator. There were no serious side-effects requiring medical attention, however some patients coughed on inhalation of the 40 mg dose and three gagged. Arterial oxygen saturation remained within normal l...Continue Reading

Citations

Sep 5, 2007·Cell and Tissue Research·Harriet NilssonGodfried M Roomans
May 20, 2003·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mohammad Reza MasjediSeyed Masoud Ghavam
Sep 2, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jeong Woong ParkYoung-Su Ju
Aug 19, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Giovanni ViegiLaura Carrozzi
Oct 13, 2004·American Journal of Respiratory and Critical Care Medicine·James N BaraniukBenjamin Nelson
Oct 8, 2013·Aerobiologia·Krzysztof FrączekDariusz Ropek
Mar 20, 1999·Chest·A H Eliasson
Nov 29, 2011·Expert Opinion on Pharmacotherapy·Asger SverrildVibeke Backer
Apr 8, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Handoko AdiDaniela Traini
Feb 26, 2016·European Clinical Respiratory Journal·Sandra D Anderson
Jul 16, 2002·Annual Review of Biomedical Engineering·David A Edwards, Craig Dunbar
May 19, 2010·Expert Review of Respiratory Medicine·John D BrannanSandra D Anderson
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H MagnussenC Taube

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